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Key Documents

T1452

Sigma-Aldrich

TPCA-1

≥95% (HPLC)

同義詞:

[5-(对-氟苯基)-2-脲基]噻吩-3-甲酰胺

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About This Item

經驗公式(希爾表示法):
C12H10FN3O2S
CAS號碼:
分子量::
279.29
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥95% (HPLC)

形狀

powder

顏色

white to light brown

溶解度

DMSO: 5 mg/mL, clear

起源

GlaxoSmithKline

儲存溫度

2-8°C

SMILES 字串

NC(=O)Nc1sc(cc1C(N)=O)-c2ccc(F)cc2

InChI

1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)

InChI 密鑰

SAYGKHKXGCPTLX-UHFFFAOYSA-N

應用

TPCA-1已用于研究其在RPMI8226和LP1细胞系中的细胞毒性作用。它还可作为培养基补充剂,用于从人气道平滑肌细胞中提取的核蛋白组分

生化/生理作用

TPCA-1是人IκB激酶-2(IKK-2)的一种有效选择性抑制剂,对于IKK-2的IC50 = 17.9 nM,而相比之下IKK-1为400 nm。它已用于研究IKK-2的抑制以防止炎症介质在关节炎和气道炎症动物模型中的释放。

特點和優勢

该化合物由 GlaxoSmithKline 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单,请单击此处

準備報告

TPCA-1可以大于或等于10 mg/ml的浓度溶于DMSO。它不可溶于水。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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