推薦產品
化驗
≥95% (HPLC)
形狀
powder
顏色
white to light brown
溶解度
DMSO: 5 mg/mL, clear
起源
GlaxoSmithKline
儲存溫度
2-8°C
SMILES 字串
NC(=O)Nc1sc(cc1C(N)=O)-c2ccc(F)cc2
InChI
1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)
InChI 密鑰
SAYGKHKXGCPTLX-UHFFFAOYSA-N
應用
TPCA-1已用于研究其在RPMI8226和LP1细胞系中的细胞毒性作用。它还可作为培养基补充剂,用于从人气道平滑肌细胞中提取的核蛋白组分。
生化/生理作用
TPCA-1是人IκB激酶-2(IKK-2)的一种有效选择性抑制剂,对于IKK-2的IC50 = 17.9 nM,而相比之下IKK-1为400 nm。它已用于研究IKK-2的抑制以防止炎症介质在关节炎和气道炎症动物模型中的释放。
特點和優勢
该化合物由 GlaxoSmithKline 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单,请单击此处。
準備報告
TPCA-1可以大于或等于10 mg/ml的浓度溶于DMSO。它不可溶于水。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。
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