推薦產品
生物源
human
重組細胞
expressed in E. coli
化驗
≥85% (SDS-PAGE)
形狀
liquid
分子量
39.5 kDa (340 aa, 27-343 aa + His Tag)
包裝
pkg of 100 μg
濃度
1 mg/mL
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... IL13RA2(3598)
一般說明
IL13Rα2 (interleukin 13 receptor subunit alpha 2) is a 42 kDa monomeric high affinity IL13 receptor. This gene is located on human chromosome Xq.
IL13RA2 is closely related to Il13RA1, a subunit of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. Recombinant human IL13RA2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
生化／生理作用
IL-13Rα2 (interleukin 13 receptor subunit α 2) induces the progression, migration and invasion of glioma cells. It has the ability to initiate Scr (selective catalytic reduction), phosphatidylinositol 3 kinase (PI3K), Akt (signaling pathway) and mTOR (mammalian target of rapamycin). IL-13Rα2 chain plays a key role in IL-13 cytotoxin-mediated therapy. It is expressed at high levels in several human tumors such as oral squamous cell carcinoma, breast cancer, clear cell renal cell carcinoma, hepatic cell cancer, ovarian cancer and colorectal cancer.
外觀
1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
IL-13 receptor α2 stimulates human glioma cell growth and metastasis through the Src/PI3K/Akt/mTOR signaling pathway.
Tu M, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(11), 14701-14709 (2016)
Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate of decline in lung function in smokers.
He JQ, et al.
American Journal of Respiratory Cell and Molecular Biology, 28(3), 379-385 (2003)
Interleukin-13 receptor α2 is associated with poor prognosis in patients with gastric cancer after gastrectomy.
Lin C, et al.
Oncotarget, 7(31), 49281-49281 (2016)
B Popovic et al.
Journal of molecular biology, 429(2), 208-219 (2016-12-14)
Interleukin (IL)-13 is a pleiotropic T helper type 2 cytokine frequently associated with asthma and atopic dermatitis. IL-13-mediated signalling is initiated by binding to IL-13Rα1, which then recruits IL-4Rα to form a heterodimeric receptor complex. IL-13 also binds to IL-13Rα2
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