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Key Documents

I4401

Sigma-Aldrich

干扰素-αA/D 人

≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture

同義詞:

IFN-αA/D

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.32

生物源

human

品質等級

重組細胞

expressed in E. coli

化驗

≥95%

形狀

buffered aqueous solution

分子量

19 kDa

包裝

pkg of 100K units

技術

cell culture | mammalian: suitable

雜質

endotoxin, tested

顏色

colorless

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... IFNA2(3440)

應用

已使用人干扰素-αA/D:
  • 用于鉴定冠状病毒复制酶抑制剂
  • 与ACH-806[1-(4-戊氧基-3-三氟甲基苯基)-3-(吡啶-3-羰基)硫脲]结合以研究对丙型肝炎病毒(HCV)复制的影响
  • 与维生素D结合用于检查细胞培养物中HCV蛋白生成的减少

生化/生理作用

干扰素-αA/D(Bg/II),也称为通用I型干扰素,是一种跨越物种屏障的α干扰素杂种。Bg/II表示由重组人干扰素αA和αD构建该杂种的限制性酶切位点。干扰素-αA/D 已被证明对许多哺乳动物细胞具有活性。它可以替代人,猴,小鼠,牛,大鼠,猫,狗,兔,绵羊,山羊,马,猪或仓鼠I型干扰素(α,β,ω 和τ)。I型干扰素是由白细胞(α亚型),成纤维细胞(β亚型),淋巴细胞(ω亚型)和反刍动物胚胎(τ亚型)产生的165-172个氨基酸蛋白的密切相关家族。该细胞因子具有抗病毒、抗增殖、免疫调节和促炎活性。

外觀

磷酸盐缓冲盐水溶液,含有 1 mg/ml牛血清白蛋白。

分析報告

在细胞病变效应抑制试验中,使用含有水泡性口炎病毒(VSV)的MDBK细胞测定生物活性。用1单位/ml干扰素可产生50%的细胞病变效应。单位是根据人干扰素αA的NIH国际标准参考确定的。

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves


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Guido Wollmann et al.
Journal of virology, 89(13), 6711-6724 (2015-04-17)
High-grade tumors in the brain are among the deadliest of cancers. Here, we took a promising oncolytic virus, vesicular stomatitis virus (VSV), and tested the hypothesis that the neurotoxicity associated with the virus could be eliminated without blocking its oncolytic
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The Journal of general virology, 85(Pt 6), 1717-1725 (2004-05-29)
A previously unknown coronavirus (CoV) is the aetiological agent causing severe acute respiratory syndrome (SARS), for which an effective antiviral treatment is urgently needed. To enable the rapid and biosafe identification of coronavirus replicase inhibitors, we have generated a non-cytopathic
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Antiviral research, 161, 1-9 (2018-10-28)
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Antimicrobial agents and chemotherapy, 52(5), 1862-1864 (2008-03-12)
Rapid emergence of resistance to monotherapy with virus-specific inhibitors necessitates combination therapy. ACH-806 is a hepatitis C virus NS4A inhibitor with a novel mechanism of action and resistance pathway. This compound was synergistic with NS3 protease inhibitors and NS5B nucleoside
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