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Key Documents

SRP0341

Sigma-Aldrich

cKit active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)

同義詞:

CD117, KIT, PBT, SCFR, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

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About This Item

CAS號碼:
分類程式碼代碼:
12352200
NACRES:
NA.32

生物源

human

重組細胞

expressed in baculovirus infected Sf9 cells

化驗

≥70% (SDS-PAGE)

形狀

aqueous solution

分子量

53.5 kDa

包裝

pkg of 10 μg

技術

activity assay: suitable
inhibition assay: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... KIT(3815)

一般說明

Human Kit ( GenBank Accession No. NM_000222), amino acids 544-976 with N-terminal His-tag, MW=50 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

應用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

單位定義

One unit is defined as the amount of enzyme that will phosphorylate 1 nmol of tyrosine substrate per minute at pH 7.4 and 30°C.

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險聲明

危險分類

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Mauro Picardo et al.
The Journal of investigative dermatology, 131(6), 1182-1185 (2011-05-14)
Cutaneous pigmentation is regulated by a complex melanogenic network in which skin cells synthesize growth factors and cytokines. Mutations in genes encoding these regulators modify their expression and/or functionality, leading to altered signaling pathways and contributing to altered skin phenotypes.
Y Yarden et al.
The EMBO journal, 6(11), 3341-3351 (1987-11-01)
Structural features of v-kit, the oncogene of HZ4 feline sarcoma virus, suggested that this gene arose by transduction and truncation of cellular sequences. Complementary DNA cloning of the human proto-oncogene coding for a receptor tyrosine kinase confirmed this possibility: c-kit

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