SML3516

EN106

≥98% (HPLC)

• 同義詞: 2-Chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide
• 經驗公式（希爾表示法）: C₁₃H₁₃ClN₂O₃
• CAS號碼: 757192-67-9
• 分子量：: 280.71
• MDL號碼: MFCD06340076
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(CCl)N(C1=CC2=C(OCCO2)C=C1)CCC#N
• InChI 密鑰: GLDJSVHDOXCYPT-UHFFFAOYSA-N

描述

生化／生理作用

Cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B that binds to C186 of FEM1B

EN106 is a cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B that binds to C186 of FEM1B. EN106 disrupts FEM1B interactions with the FNIP1 degron and inhibits CUL2FEM1B-dependent ubiquitylation without detectable off-target effects. A modified EN106 bifunctional analog (PROTAC) recruits FEM1B and induces targeted BRD4 and BCR-ABL/c-ABL degradation.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable