SML3433

NVP-TNKS656

≥98% (HPLC)

• 同義詞: ; N-Cyclopropylmethyl-2-[4-(4-methoxybenzoyl)piperidin-1-yl]-N-[(4-oxo-4,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]acetamide, N-​(Cyclopropylmethyl)​-​4-​(4-​methoxybenzoyl)​-​N-​[(3,​5,​7,​8-​tetrahydro-​4-​oxo-​4H-​pyrano[4,​3-​d]​pyrimidin-​2-​yl)​methyl]​-​piperidineacetamide, NVP-TNKS 656, TNKS656
• 經驗公式（希爾表示法）: C₂₇H₃₄N₄O₅
• CAS號碼: 1419949-20-4
• 分子量：: 494.58
• MDL號碼: MFCD28167762
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C
• InChI: 1S/C27H34N4O5/c1-35-21-6-4-19(5-7-21)26(33)20-8-11-30(12-9-20)16-25(32)31(14-18-2-3-18)15-24-28-23-10-13-36-17-22(23)27(34)29-24/h4-7,18,20H,2-3,8-17H2,1H3,(H,28,29,34)
• InChI 密鑰: DYGBNAYFDZEYBA-UHFFFAOYSA-N

描述

生化／生理作用

NVP-TNKS656 is an orally active, highly potent and selective tankyrase inhibitor. NVP-TNKS656 is a potent antagonist of Wnt pathway that reverts resistance to PI3K and AKT inhibitors in treatment of colorectal cancer.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable