SML3252

SF3B1 Protein Degrader

≥95% (HPLC)

• 同義詞: 2-((4-chlorophenyl)amino)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)thiazole-4-carboxamide, O4I2-based PROTAC^® degrader
• 經驗公式（希爾表示法）: C₂₉H₂₉ClN₆O₅S
• 分子量：: 609.10
• 分類程式碼代碼: 12352202
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: powder
• 儲存條件: under inert gas
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: O=C1N(C(C2=C1C=CC=C2NCCCCCCNC(C3=CSC(NC4=CC=C(C=C4)Cl)=N3)=O)=O)C5CCC(NC5=O)=O

描述

生化／生理作用

SF3B1 Protein degrader (reported as "PROTAC-O4I2" in Gama-Brambila et al.) is a cell permeable degrader of splicing factor 3B1 (SF3B1) containing an SF3B1 activator O4I2 connected to the ligand of the cereblon ubiquitin ligase thalidomide. PROTAC-O4I2 selectively degrades SF3B1 in cells. It induces apoptosis of tumor cells and extends survival in Drosophila intestinal tumor model.

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable