SML2950

E7820

≥98% (HPLC)

• 同義詞: 3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide, 3-Cyano-N-(3-cyano-4-methyl-1H-indole-7-yl)benzensulfonamide, E 7820, NSC 719239
• 經驗公式（希爾表示法）: C₁₇H₁₂N₄O₂S
• CAS號碼: 289483-69-8
• 分子量：: 336.37
• MDL號碼: MFCD09833234
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• ligand: E7820
• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 反應適用性: reagent type: ligand
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C
• InChI: 1S/C17H12N4O2S/c1-11-5-6-15(17-16(11)13(9-19)10-20-17)21-24(22,23)14-4-2-3-12(7-14)8-18/h2-7,10,20-21H,1H3
• InChI 密鑰: LWGUASZLXHYWIV-UHFFFAOYSA-N

描述

生化／生理作用

E7820 (NSC 719239) is an orally available anticancer and antiangiogenic agent that inhibits VEGF-2 or FGF-2-induced tube formation of HUVEC cells through the suppression of integrin α2. E7820 promotes selective proteasomal degradation of the U2AF-related splicing factor CAPERα (coactivator of activating protein-1 and estrogen receptors) by ubiquitination and degradation via CRL4DCAF15.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable