5.08159

Salvinorin A

• 同義詞: Salvinorin A, κ-opioid Receptor Agonist, Salvinorin A, Divinorin A
• 經驗公式（希爾表示法）: C₂₃H₂₈O₈
• CAS號碼: 83729-01-5
• 分子量：: 432.46
• MDL號碼: MFCD05664742
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 品質等級: 100
• 形狀: solid
• 效力: 4.3 nM K_i
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: ethanol: 10 mM; DMSO: 50 mM
• 儲存溫度: −70°C
• InChI: 1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1
• InChI 密鑰: OBSYBRPAKCASQB-AGQYDFLVSA-N

描述

一般說明

A highly potent and selective non-alkaloid positive allosteric modulator of Κ-opioid receptors (K_i = 4.3 nM and 16 nM for native and cloned κ-opioid receptors, respectively). Also acts as a D2DR partial agonist (K_i = 5-10 nM). Used in studies of addition.

生化／生理作用

Primary Target
k opioid receptor

警告

Toxicity: Standard Handling (A)

其他說明

Roth, B. et al., 2002. PNAS.99, 11934.
Valdés III., j., et al., 1984. J. Organic Chem.49, 4716.
Ortega, A., et al., 1982. J. of Chem. Society, Perkins Transactions I. 2505.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3