推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
ClC1=C(NC2=C(C(NO)=O)C=CC=C2)C(Cl)=CC(C3=C(C)ON=C3C)=C1
InChI
1S/C18H15Cl2N3O3/c1-9-16(10(2)26-23-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(24)22-25/h3-8,21,25H,1-2H3,(H,22,24)
InChI 密鑰
ILHNIWOZZKIBNW-UHFFFAOYSA-N
生化／生理作用
FB23-2 can also prevent osteogenic differentiation of human mesenchymal stem cells (MSCs). It is capable of delaying leukemogenesis in vivo. In mice, FB23-2 at a dose of 20 mg/kg is safe for testing in vivo efficacy.
FB23-2 is a cell penetrant, potent and specific inhibitor of N6-methyladenosine (m6A) demethylase FTO (fat mass and obesity associated protein) that RNA methylation in varies of AML cells. FB23-2 potently inhibits proliferation and promotes apoptosis and differentiation in human acute myeloid leukemia (AML) cells and primary blast AML cells lines and xenografts in mice. It minimally affects proliferation of human normal bone marrow cells.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Yue Huang et al.
Cancer cell, 35(4), 677-691 (2019-04-17)
FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis. Using structure-based rational design, we have developed two promising FTO inhibitors, namely FB23 and FB23-2, which directly bind to FTO and selectively inhibit FTO's m6A demethylase activity. Mimicking FTO
The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG.
Liu-Shan Chen et al.
Acta pharmacologica Sinica, 43(5), 1311-1323 (2021-09-01)
N6-methyladenosine (m6A) is the most abundant posttranscriptional methylation modification that occurs in mRNA and modulates the fine-tuning of various biological processes in mammalian development and human diseases. In this study we investigated the role of m6A modification in the osteogenesis
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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