SML1925

Bepristat 2a hydrochloride

≥95% (HPLC)

• 同義詞: 6-Bromo-2-[[[2-(diethylamino)ethyl]amino]methyl]-5-hydroxy-1-phenyl-1H-indole-3-carboxylic acid ethyl ester hydrochloride
• 經驗公式（希爾表示法）: C₂₄H₃₀BrN₃O₃ · xHCl
• CAS號碼: 2140803-90-1
• 分子量：: 488.42 (free base basis)
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to beige
• 溶解度: H₂O: 10 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: CCN(CC)CCNCC1=C(C(OCC)=O)C2=CC(O)=C(Br)C=C2N1C3=CC=CC=C3.[H]Cl
• InChI 密鑰: HKOKWSVFJJFYDV-UHFFFAOYSA-N

描述

生化／生理作用

Bepristat 2a is a selective reversible inhibitor of protein disulfide isomerase (PDI), an enzyme in the endoplasmic reticulum that catalyzes disulfide bond breakage and reformation to catalyze protein folding. Unlike most PDI inhibitors, Bepristat 2a binds at the substrate-binding site, rather than the catalytic site. Bepristat 2a blocked PDI activity with an IC₅₀ value of 1200 nM, while enhancing catalytic activity of remote PDI domains. PDI is up-regulated in several cancers, has been implicated in neurodegenerative processes, and plays an important role in thrombus formation. Bepristat 2a potently inhibited platelet aggregation and thrombus formation in vivo.

Bepristat 2a is a selective reversible inhibitor of protein disulfide isomerase (PDI).

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable