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Key Documents

SML1906

Sigma-Aldrich

AS1517499

≥98% (HPLC)

同義詞:

2-[ [2-(3-氯-4-羟基苯基)乙基] 氨基]-4-[(苯甲基)氨基]-5-嘧啶甲酰胺, 4-(苄氨基)-2-{ [2-(3-氯-4-羟基苯基)乙基] 氨基 } 嘧啶-5-甲酰胺

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About This Item

經驗公式(希爾表示法):
C20H20ClN5O2
CAS號碼:
分子量::
397.86
MDL號碼:
分類程式碼代碼:
12352200

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

ClC1=CC(CCNC2=NC=C(C(N)=O)C(NCC3=CC=CC=C3)=N2)=CC=C1O

InChI

1S/C20H20ClN5O2/c21-16-10-13(6-7-17(16)27)8-9-23-20-25-12-15(18(22)28)19(26-20)24-11-14-4-2-1-3-5-14/h1-7,10,12,27H,8-9,11H2,(H2,22,28)(H2,23,24,25,26)

InChI 密鑰

OZRMEKAUZBKTTC-UHFFFAOYSA-N

生化/生理作用

AS1517499 是一种有效的 STAT6(信号转导子和转录激活子 6)抑制剂(IC 50 = 21 nM,抑制 IL-4 依赖性报告基因活性),可选择性地阻止抗 CD3-和IL-4 诱导小鼠脾脏 T 细胞的辅助性 T 细胞 2 (Th2) 分化 (IC 50 = 2.3 nM),并且不影响抗 CD3和IL-12 诱导 Th1 分化。AS1517499的体内功效在各种免疫性疾病动物模型中得到证实,包括自身免疫性Graves病,抗原诱导的支气管过度收缩(10 mg / kg i.p.)。
AS1517499适度抑制RhoA(ras同源家族A)的表达。 RhoA蛋白的过表达与过敏性支气管哮喘有关。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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