推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
光學活性
[α]/D +68 to +78°, c = 1 in chloroform-d
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
−20°C
InChI
1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
InChI 密鑰
WOXKDUGGOYFFRN-IIBYNOLFSA-N
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生化／生理作用
Tadalafil is a potent, selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) used to treat erectile dysfunction, pulmonary hypertension, and benign prostatic hyperplasia (BPH).
This β-carboline-based drug has a long elimination half-life of about 18 hours.
This β-carboline-based drug has a long elimination half-life of about 18 hours.
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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International journal of urology : official journal of the Japanese Urological Association, 24(3), 206-210 (2016-12-30)
To investigate the effects of tadalafil on vascular endothelial function and cardiovascular risk in patients with prostatic hyperplasia. Tadalafil 5 mg was given to 20 patients with prostatic hyperplasia for whom an α1-blocker was ineffective. Voiding symptoms and vascular endothelial
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Urology journal, 13(6), 2920-2926 (2016-12-09)
To compare monotherapy with tadalafil or tamsulosin and their combination therapy in men with benignprostatic hyperplasia and erectile dysfunction by comparing IPSS score, prostate volume and Qmax and someother outcomes. This randomized, single-blind, paralleled group clinical trial was done in
Alaa E El-Sisi et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 84, 861-869 (2016-10-14)
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A once-daily dose of tadalafil for erectile dysfunction: compliance and efficacy.
Washington III S L and Shindel A W
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Luqiang Wang et al.
American journal of physiology. Endocrinology and metabolism, 315(4), E446-E453 (2018-06-20)
Cyclic GMP (cGMP) is an important intracellular regulator of endochondral bone growth and skeletal remodeling. Tadalafil, an inhibitor of the phosphodiesterase (PDE) type 5 (PDE5) that specifically hydrolyzes cGMP, is increasingly used to treat children with pulmonary arterial hypertension (PAH)
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