SML1726

MSAB

≥95% (HPLC)

• 同義詞: 3-[[(4-Methylphenyl)sulfonyl]amino]-benzoic acid methyl ester, Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate, WI-21
• 經驗公式（希爾表示法）: C₁₅H₁₅NO₄S
• CAS號碼: 173436-66-3
• 分子量：: 305.35
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329826041
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: powder
• 顏色: off-white to purple
• 溶解度: DMSO: 25 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: CC1=CC=C(S(NC2=CC(C(OC)=O)=CC=C2)(=O)=O)C=C1
• InChI 密鑰: CVKBYFCJQSPBOI-UHFFFAOYSA-N

描述

生化／生理作用

A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth.

A cellular β-catenin degradation inducer with anti-proliferation efficacy against Wnt-dependent cancer growth both in vitro and in vivo.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable