SML1578

Aftin-4

≥98% (HPLC)

• 同義詞: (2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, Amyloid-β Forty-Two Inducer 4, N6-Methyl-(R)-roscovitine
• 經驗公式（希爾表示法）: C₂₀H₂₈N₆O
• CAS號碼: 866893-90-5
• 分子量：: 368.48
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: protect from light
• 顏色: white to beige
• 溶解度: DMSO: 25 mg/mL, clear
• 儲存溫度: −20°C

描述

生化／生理作用

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3