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Key Documents

5.00554

Sigma-Aldrich

MHY1485

≥97% (HPLC), solid, mTOR activator, Calbiochem®

同義詞:

mTOR活化剂,MHY1485

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About This Item

經驗公式(希爾表示法):
C17H21N7O4
CAS號碼:
分子量::
387.39
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

product name

mTOR活化剂,MHY1485,

化驗

≥97% (HPLC)

品質等級

形狀

solid

效力

~2 μM IC50

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

pale yellow

溶解度

DMSO: 12.5 mg/mL

儲存溫度

2-8°C

SMILES 字串

C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC(=NN3)C4=CC=CC=C4O

一般說明

MHY1485, a small-molecule activator of the mammalian target of rapamycin (mTOR), exerts an inhibitory effect on the autophagic process by preventing the fusion between autophagosomes and lysosomes, resulting in the accumulation of LC3II protein and the enlargement of autophagosomes. It can also protect osteoblasts from dexamethasone-induced damage by inhibiting the mitochondrial death pathway provoked by dexamethasone.

應用

mTOR Activator, MHY1485 has been used to activate the mammalian target of rapamycin (mTOR) pathway in mice with Parkinson disease (PD) to reverse the effects of tumor necrosis factor α–induced protein 3 (TNFAIP3) on the mitigation of injury in mice and in SK-N-SH cells induced with 1-Methyl-4-phenylpyridinium (MPP+).

生化/生理作用

可逆性:是
细胞可渗透性:具有

包裝

用惰性气体包装

警告

毒性:标准处理(A)

重構

溶解后,等分并冷冻保存(-20°C)。储备溶液在-20°C下可稳定保存至多3个月。

其他說明

Choi, Y. J., et al. 2012.PLoS.One.7, e43418.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Yeon Ja Choi et al.
PloS one, 7(8), e43418-e43418 (2012-08-29)
Autophagy is a major degradative process responsible for the disposal of cytoplasmic proteins and dysfunctional organelles via the lysosomal pathway. During the autophagic process, cells form double-membraned vesicles called autophagosomes that sequester disposable materials in the cytoplasm and finally fuse

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