SML1060

塞来昔布-NBD

≥98% (HPLC)

• 同義詞: N-(2-((7-Nitrobenzo[c]-[1,2,5]oxadiazol-4-yl)amino)ethyl)-4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
• 經驗公式（希爾表示法）: C₂₅H₂₀F₃N₇O₅S
• 分子量：: 587.53
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: protect from light
• 顏色: yellow to orange
• 溶解度: DMSO: 10 mg/mL, clear
• 儲存溫度: 2-8°C

描述

生化／生理作用

Celecoxib-NBD is a flourescent COX2-specific inhibitor.

Celecoxib-NBD is a flourescent COX2-specific inhibitor. The molecule binds to, and inhibits COX2 with an IC₅₀ of 0.19 μM, and a selectivity index of 443 for COX2 vs. COX1. Celecoxib-NBD fluorescently labels COX2-expressing HCA-7 colon cells, but not COX2-negative HCT116 cells.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301,H413
• 防範說明: P264 - P270 - P273 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 3 Oral - Aquatic Chronic 4
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable