推薦產品
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to beige
溶解度
H2O: 1 mg/mL, clear (warmed)
儲存溫度
−20°C
InChI
1S/C17H27NO9/c1-8(2)24-17-14(18-9(3)19)16(26-12(6)22)15(25-11(5)21)13(27-17)7-23-10(4)20/h8,13-17H,7H2,1-6H3,(H,18,19)/t13-,14-,15-,16-,17+/m1/s1
InChI 密鑰
KMIQMFHPUJUDMC-HHARLNAUSA-N
一般說明
TLR4-IN-C34 是体外和体内 toll 样受体 4（TLR4）的抑制剂。
應用
TLR4-IN-C34 已作为一种抑制剂用在喂食高脂饮食的小鼠中，以在体内验证上述体外途径（硬脂酸/LDH-α/细胞因子）。
生化／生理作用
TLR4-IN-C34 是 toll 样受体 4（TLR4）的有效和特异性抑制剂，其在体内和体外抑制 TLR4 信号转导。TLR4-IN-C34，也称为 C34，是一种氨基单糖，通过与 TLR4 的共同受体-髓样分化蛋白-2 (MD-2)的疏水口袋对接来抑制 TLR4 信号。研究表明，C34 可降低实验性坏死性小肠结肠炎（NEC）的严重程度。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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Peter Wipf et al.
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The low-molecular weight isopropyl 2-acetamido-α-glucoside 16 (C34) inhibits toll-like receptor 4 (TLR4) in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. We used a copper(II)-mediated solvolysis of anomeric oxazolines and an
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Journal of applied toxicology : JAT, 39(6), 832-843 (2019-01-24)
This study investigated the pharmacological inhibition of the toll-like receptor 4 (TLR4) genes as a measure to attenuate microcystin-LR (MC-LR) reproductive toxicity. Bovine Sertoli cells were pretreated with TLR4-IN-C34 (C34) for 1 hour. Thereafter the pretreated and non-pretreated Sertoli cells were
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Journal of applied toxicology : JAT, 39(6), 832-843 (2019-01-24)
This study investigated the pharmacological inhibition of the toll-like receptor 4 (TLR4) genes as a measure to attenuate microcystin-LR (MC-LR) reproductive toxicity. Bovine Sertoli cells were pretreated with TLR4-IN-C34 (C34) for 1 hour. Thereafter the pretreated and non-pretreated Sertoli cells were
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Journal of neuroinflammation, 15(1), 139-139 (2018-05-13)
Parkinson's disease (PD) is characterized by selective degeneration of dopaminergic (DA) neurons of the substantia nigra pars compacta (SN) while neighboring ventral tegmental area (VTA) DA neurons are relatively spared. Mechanisms underlying the selective protection of the VTA and susceptibility
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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