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Merck
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重要文件

P4154

Sigma-Aldrich

聚肌苷酸 钾盐

Homopolymer

同義詞:

聚(I) 钾盐

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About This Item

CAS號碼:
MDL號碼:
分類程式碼代碼:
41106305
NACRES:
NA.51

生物源

synthetic (organic)

品質等級

化驗

≥98% (TLC)

形狀

lyophilized powder

溶解度

water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow

儲存溫度

−20°C

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應用

聚肌苷酸(聚(I))是一种肌苷的均聚物,其可与聚胞苷酸(聚(C))一起形成双链均聚物(聚(I)·聚(C))。 TLR3 识别双链 RNA,并且是针对病毒病原体的免疫应答的主要效应分子。(Poly(I)•Poly(C))被用作研究 TLR3 水平的细胞信号传导的模型 RNA。Poly(IC)是一种 TRIF 依赖性 toll 样受体-3(TLR3)配体。

準備報告

通过多核苷酸磷酸化酶法从 IDP 制备。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

Lot/Batch Number

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存取文件庫

Overlapping and distinct roles of GRK5 in TLR2-, and TLR3-induced inflammatory response in vivo.
Packiriswamy N, Parvataneni S, Parameswaran N.
Cellular Immunology, 107-111 (2011)
Xingbo Wang et al.
Veterinary microbiology, 251, 108895-108895 (2020-10-31)
RNA binding ability and cellular distribution are important for nonstructural protein 1 (NS1) of influenza A virus to act as a viral regulatory factor to control virus life cycle. In this study, we identified that the N-terminal residues 19-21 of
Gennady Dvoryanchikov et al.
Nature communications, 8(1), 760-760 (2017-10-04)
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Activation of chemokine and inflammatory cytokine response in HCV-infected hepatocytes depends on TLR3 sensing of HCV dsRNA intermediates.
Li K, Li NL, Wei D, Pfeffer SR, et al.
Hepatology, 55(3), 666-675 (2011)
Caiqi Ma et al.
International journal of oncology, 54(2), 572-584 (2018-11-30)
Gastric cancer is one of the most malignant tumor types, and its metastasis is a notable cause of mortality. Among the methods of tumor metastasis, lymphatic metastasis is the predominant one in gastric cancer. A previous study reported that the

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