推薦產品
應用
TLR3可识别双链RNA，是病毒病原体免疫应答的主要效应物。 聚肌苷酸-聚胞苷酸 (Poly(I) • Poly(C))是一种双链均聚物，可作为模型RNA，用于研究在TLR3水平下的细胞信号传导。 Poly(IC)是TRIF依赖型toll样受体3（TLR3）的配体。
生化／生理作用
将Poly(I:C)转染至NIT-1细胞中，已被用作细胞内dsRNA诱导的β细胞凋亡的模型。转染后18小时，45％的细胞发生凋亡，并且其NF-kB、p50/p65核转位、caspase 3和8切割以及caspase 12的转录诱导、Fas、IL-15和TNF受体相关配体（TRAIL）水平均增加。有人提出Poly(I:C)是最合适的稳定成熟树突状细胞（DC）诱导剂之一。这些成熟DC能够在CD40连接后分泌生物活性IL-12，因此注射后能够在体内产生有效的免疫应答。Poly(I:C)被用作有效的佐剂，以增强对肽类疫苗的特异性抗肿瘤免疫应答。
包裝
包装规格取决于多核苷酸含量
其他說明
双链均聚物。
準備報告
本品需要离子强度，以维持双链结构。用水复溶至浓度约为10 mg/mL，获得溶于生理磷酸盐缓冲溶液的多核苷酸。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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