推薦產品
產品名稱
A 83-01, ≥98% (HPLC)
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 5 mg/mL, clear (warmed)
儲存溫度
−20°C
SMILES 字串
S=C([n]2nc(c(c2)c4c5c(ncc4)cccc5)c3nc(ccc3)C)Nc1ccccc1
InChI
1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)
InChI 密鑰
HIJMSZGHKQPPJS-UHFFFAOYSA-N
一般說明
A-83-01可有效抑制烧伤创面收缩而不影响创面愈合,因为它可抑制转化生长因子-β (TGF-β)诱导的肌成纤维细胞群增加。此外,还可通过抑制动物的上皮间质转化(EMT)来阻止TGF-β1-依赖的癌症转移。
應用
A 83-01已用于:
- 加入培养基用于分离肿瘤细胞的类器官形成,
- 加入杜氏改良Eagle培养基/F-12营养混合物(DMEM/F12)中以培养人表皮干细胞(EpSCs)
A 83-01已被用作转化生长因子β激酶1型受体的抑制剂。
生化/生理作用
A 83-01是一种TGFβ激酶/激活素受体样激酶(ALK 5)的抑制剂(IC50= 12nM),可阻止Smad2/3的磷酸化并抑制TGFβ诱导的生长。 A 83-01可阻断Smad2的磷酸化并抑制TGF-β诱导的上皮-间质转化。 此外,A 83-01可抑制由TGFβI型受体ALK-5、活化素IB型受体ALK-4、和结节型I受体ALK-7诱导的转录活性。 A-83-01可诱导新生Nkx2.5-eGFP(+)细胞的扩增。
A-83-01是一种TGFβ激酶/激活素受体样激酶(ALK 5)抑制剂。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
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