SML0683

JNJ-40418677

≥98% (HPLC)

• 同義詞: 2-(S)-(3,5-Bis(4-(trifluoromethyl)phenyl)phenyl)-4-methylpentanoic acid
• 經驗公式（希爾表示法）: C₂₆H₂₂F₆O₂
• CAS號碼: 1146594-87-7
• 分子量：: 480.44
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 15 mg/mL, clear
• 起源: Johnson & Johnson
• 相關疾病: Alzheimer′s disease
• 儲存溫度: 2-8°C

描述

生化／生理作用

JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting processing of Notch. In human neuroblastoma cells and rat primary neuronal cultures, JNJ-40418677 blocked secretion of Aβb42 (IC₅₀ = 20 nM), with no affects on total Ab concentration, Notch signaling or COX activity. In vivo experiments showed that JNJ-40418677 dose dependently inhibited Aβ42 accumulation in the brain while promoting an increase in Aβ38.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300,H413
• 防範說明: P264 - P270 - P273 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 2 Oral - Aquatic Chronic 4
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable