全部照片(1)
About This Item
經驗公式（希爾表示法）:
C15H11F2N3
CAS號碼:
分子量：:
271.26
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 15 mg/mL (clear solution)
儲存溫度
2-8°C
SMILES 字串
FC1=CC=C(C=C1)CNC2=C3C=C(F)C=CC3=NC=N2
InChI
1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
InChI 密鑰
AWIVHRPYFSSVOG-UHFFFAOYSA-N
應用
Spautin-1 已作为自噬抑制剂用于：
- 研究其对氧诱导视网膜病变小鼠模型中血管、神经胶质和神经元改变的影响
- 评估预处理对犬骨肉瘤细胞阿霉素反应的效果
- 在 Luminex 试验中研究其对氧化应激树突状细胞 (OS-DC) 产生白细胞介素 (IL)-6 的影响
生化／生理作用
Spautin-1 抑制两种泛素特异性肽酶 USP10 和 USP13 的活性，引起 III 类 PI3 激酶复合物的蛋白酶体降解增加，已被证明可调节自噬。
Spautin-1 是一种自噬抑制剂。
特异性强的自噬抑制剂-1（Spautin-1）是一种小分子，可以抑制自噬并诱导癌细胞死亡。它可通过降解 beclin-1 来抑制自噬。Spautin-1 可提高放射治疗和化学疗法在各种人类癌细胞系中的效率。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 4 Oral - Eye Dam. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
客戶也查看了
Alice Verchère et al.
Scientific reports, 2, 306-306 (2012-03-09)
We describe an original activity assay for membrane transport that uses the proton motive force-dependent efflux pump MexAB from Pseudomonas aeruginosa. This pump is co-reconstituted into proteoliposomes together with bacteriorhodopsin (BR), a light-activated proton pump. In this system, upon illumination
Daniel G Panaccione et al.
Scientific reports, 7(1), 8930-8930 (2017-08-23)
Neosartorya fumigata (Aspergillus fumigatus) is the most common cause of invasive aspergillosis, a frequently fatal lung disease primarily affecting immunocompromised individuals. This opportunistic fungal pathogen produces several classes of specialised metabolites including products of a branch of the ergot alkaloid
Ge Yang et al.
Scientific reports, 7(1), 17970-17970 (2017-12-23)
Presenilin (PS1 or PS2) functions as the catalytic subunit of γ-secretase, which produces the toxic amyloid beta peptides in Alzheimer's disease (AD). The dependence of folding and structural stability of PSs on the lipophilic environment and mutation were investigated by
Kuntal Ganguly et al.
Drug delivery, 23(8), 2838-2851 (2015-11-05)
Microspheres of chitosan (CS) cross-linked with polyethylene glycol (PEG) were prepared by emulsion-cross-linking followed by the solvent evaporation technique. The formulations were characterized and subjected to in vitro and in vivo tests to assess cell growth, changes in cell morphology
Yanbin Ma et al.
PloS one, 8(2), e56500-e56500 (2013-02-26)
N-terminally his-tagged human mu opioid receptor, a G protein-coupled receptor was produced in E.coli employing synthetic codon-usage optimized constructs. The receptor was expressed in inclusion bodies and membrane-inserted in different E.coli strains. By optimizing the expression conditions the expression level
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務