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SML0360

Sigma-Aldrich

TAK-715

≥98% (HPLC)

同義詞:

N-(4-(2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide

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About This Item

經驗公式（希爾表示法）:
C24H21N3OS
CAS號碼:
303162-79-0
分子量：:
399.51
MDL號碼:
MFCD17012805
分類程式碼代碼:
12352200
PubChem物質ID:
329825362
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

faintly yellow to dark yellow

溶解度

DMSO: >15 mg/mL

儲存溫度

2-8°C

SMILES 字串

CCc1nc(-c2cccc(C)c2)c(s1)-c3ccnc(NC(=O)c4ccccc4)c3

InChI

1S/C24H21N3OS/c1-3-21-27-22(18-11-7-8-16(2)14-18)23(29-21)19-12-13-25-20(15-19)26-24(28)17-9-5-4-6-10-17/h4-15H,3H2,1-2H3,(H,25,26,28)

InChI 密鑰

HEKAIDKUDLCBRU-UHFFFAOYSA-N

基因資訊

human ... MAPK14(1432)

相關類別

生化／生理作用

TAK-715 is a dual p38 MAPK and CKId/e inhibitor; inhibitor of Wnt-3a-stimulated β-catenin signaling.
TAK-715 is a potent p38 inhibitor that also inhibits CKId/e (casein kinase Id/e), known activator of Wnt/β-catenin signaling.

特點和優勢

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302,H319

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

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Jonathan Oliva et al.
The Journal of pharmacology and experimental therapeutics, 370(2), 219-230 (2019-06-14)
Facioscapulohumeral muscular dystrophy (FSHD) is characterized by misexpression of the double homeobox 4 (DUX4) developmental transcription factor in mature skeletal muscle, where it is responsible for muscle degeneration. Preventing expression of DUX4 mRNA is a disease-modifying therapeutic strategy with the
Jean-Philippe Coppé et al.
Nature cell biology, 21(6), 778-790 (2019-06-05)
Phosphorylation networks intimately regulate mechanisms of response to therapies. Mapping the phospho-catalytic profile of kinases in cells or tissues remains a challenge. Here, we introduce a practical high-throughput system to measure the enzymatic activity of kinases using biological peptide targets

文章

MAPKs

The mitogen-activated protein kinase (MAPK) family consists of both stress activated (SAPK) and mitogen-activated (MAPK) protein kinases. They form a network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli, including growth factors, chemical or osmotic stress, irradiation, bacterial infection and proinflammatory cytokines.

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