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Key Documents

SML0350

Sigma-Aldrich

AZD-7762 hydrochloride

≥98% (HPLC)

同義詞:

5-(3-Fluorophenyl)-3-ureidothiophene-2-carboxylic acid N-[(S)-piperidin-3-yl]amide hydrochloride, AZD 7762 hydrochloride

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About This Item

經驗公式(希爾表示法):
C17H19FN4O2S · HCl
CAS號碼:
分子量::
398.88
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to light brown

溶解度

DMSO: 15 mg/mL, clear

儲存溫度

−20°C

SMILES 字串

Cl.NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)-c3cccc(F)c3

InChI

1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1

InChI 密鑰

WFZBLOIXZRZEDG-YDALLXLXSA-N

應用

AZD-7762 hydrochloride has been used:
  • as a checkpoint kinase 1 and 2 (CHK1/2) inhibitor to study its effect on the efficiency of non-homologous end-joining (NHEJ) repair in breast cancer cell lines
  • as a CHK1 inhibitor to serve as a positive control for replication stress in the assessment of fork restart events
  • as a CHK1/2 inhibitor to study its effects on DNA lesions during mice zygote development

生化/生理作用

AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2 that enhanced cytotoxicity DNA-damaging agents.

象形圖

CorrosionExclamation mark

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 4 Oral - Eye Dam. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Sabrina Ladstätter et al.
Cell, 167(7), 1774-1787 (2016-12-06)
Sexual reproduction culminates in a totipotent zygote with the potential to produce a whole organism. Sperm chromatin reorganization and epigenetic reprogramming that alter DNA and histone modifications generate a totipotent embryo. Active DNA demethylation of the paternal genome has been
Peter Tonzi et al.
eLife, 7 (2018-11-14)
DNA replication stress is often defined by the slowing or stalling of replication fork progression leading to local or global DNA synthesis inhibition. Failure to resolve replication stress in a timely manner contribute toward cell cycle defects, genome instability and

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