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Merck
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Key Documents

SCP0081

Sigma-Aldrich

Caspase 3 Apopain Substrate

≥95% (HPLC), lyophilized

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About This Item

經驗公式(希爾表示法):
C30H34N5O13
分子量::
672.62
分類程式碼代碼:
12352202
NACRES:
NA.32

product name

Caspase 3 Apopain Substrate,

化驗

≥95% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥85%

儲存條件

protect from light

儲存溫度

−20°C

Amino Acid Sequence

Ac-Asp-Glu-Val-Asp-7-AFC

應用

Ac-DEVD-7-AFC (N-acetyl-asp-glu-val-asp-7-amino-4-trifluoromethyl coumarin) is used as a cell penetrating fluorogenic CED-related caspase substrate.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Caspase activation by anticancer drugs: the caspase storm.
Tao Z, Goodisman J, Penefsky HS, et al.
Molecular Pharmacology, 4, 583-595 (2007)
Benjawan Wudtiwai et al.
Journal of hematology & oncology, 4, 52-52 (2011-12-22)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various tumor cells, but does not affect normal cells or human leukemic cells, such as MOLT-4 and U937 cells, which are relatively resistant to TRAIL. Three flavonoids extracted from the rhizome
R A Jones et al.
Hepatology (Baltimore, Md.), 27(6), 1632-1642 (1998-06-10)
The mechanism of Fas antigen-induced hepatocyte apoptosis was investigated. Using a monoclonal antibody directed against the Fas antigen, apoptosis was induced in freshly isolated murine hepatocytes within 90 minutes of antibody addition as assessed by plasma membrane bleb formation, chromatin
Kateřina Kuželová et al.
Journal of cellular biochemistry, 112(11), 3334-3342 (2011-07-14)
The effects of the pan-caspase inhibitor Q-VD-OPh on caspase activity, DNA fragmentation, PARP cleavage, 7A6 exposition, and cellular adhesivity to fibronectin were analyzed in detail in three different apoptotic systems involving two cell lines (JURL-MK1 and HL60) and two apoptosis

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