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Key Documents

B4153

Sigma-Aldrich

Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride

~95%

同義詞:

Boc-Gln-Ala-Arg-AMC hydrochloride, Boc-Gln-Ala-Arg-Mca hydrochloride

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About This Item

經驗公式(希爾表示法):
C29H42N8O8 · HCl
CAS號碼:
分子量::
667.15
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.32

化驗

~95%

品質等級

形狀

powder

溶解度

methanol: 50 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

CC(NC(=O)C(CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)NC(CCCNC(N)=N)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C29H42N8O8/c1-15-13-23(39)44-21-14-17(8-9-18(15)21)35-26(42)19(7-6-12-33-27(31)32)36-24(40)16(2)34-25(41)20(10-11-22(30)38)37-28(43)45-29(3,4)5/h8-9,13-14,16,19-20H,6-7,10-12H2,1-5H3,(H2,30,38)(H,34,41)(H,35,42)(H,36,40)(H,37,43)(H4,31,32,33)

InChI 密鑰

LQSLBVXESNRILG-UHFFFAOYSA-N

一般說明

Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride is a fluorogenic and cell-permeable trypsin substrate.

應用

Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride has been used as a fluorogenic substrate to measure the enzymatic activity of trypsin.

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

基底

Substrate for trypsin

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Cellular and molecular life sciences : CMLS, 77(9), 1811-1825 (2019-08-01)
Premature intrapancreatic trypsinogen activation is widely regarded as an initiating event for acute pancreatitis. Previous studies have alternatively implicated secretory vesicles, endosomes, lysosomes, or autophagosomes/autophagolysosomes as the primary site of trypsinogen activation, from which a cell-damaging proteolytic cascade originates. To
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S Kawabata et al.
European journal of biochemistry, 172(1), 17-25 (1988-02-15)
Seventy-four peptide amides of 7-amino-4-methylcoumarin (Mec) of the type Boc-Xaa-Yaa-Arg-NH-Mec were newly synthesized and tested to find specific substrates for blood-clotting proteases and trypsin. The Xaa and Yaa residues of these substrates have been replaced by 12 and 15 different
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PloS one, 16(4), e0248356-e0248356 (2021-04-10)
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