SAB4300468

Anti-PTK2B (Ab-402) antibody produced in rabbit

affinity isolated antibody

• 同義詞: Anti-CADTK antibody produced in rabbit, Anti-CAKB antibody produced in rabbit, Anti-FADK2 antibody produced in rabbit, Anti-FAK2 antibody produced in rabbit, Anti-PTK2B protein tyrosine kinase 2 beta antibody produced in rabbit
• MDL號碼: MFCD01634069
• 分類程式碼代碼: 12352203
• NACRES: NA.41
• 無性繁殖: polyclonal
• application: IF; IHC (p); WB
• 物種活性: rat, mouse, human
• 技術: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• citations: 6

屬性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: ~116 kDa
• 物種活性: rat, mouse, human
• 濃度: 1 mg/mL
• 技術: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• 同型: IgG
• 免疫原序列: (D-I-Y-A-E)
• NCBI登錄號: NP_004094.3
• UniProt登錄號: Q14289
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... PTK2B(2185)

描述

一般說明

PTK2B/ Pyk2 (proline-rich tyrosine kinase 2β) is a non receptor protein kinase that belongs to the focal adhesion kinase family. It is also known as FAK2 (focal adhesion kinase 2), RAFTK (related adhesion focal tyrosine kinase) and CAKB (cell adhesion kinase beta). Its expression is confined to the endothelium, central nervous system and hematopoietic lineages. It is located on human chromosome 8p21.1.

免疫原

Peptide sequence around aa. 400-404 (D-I-Y-A-E), according to the protein PTK2B.

應用

Anti-PTK2B (Ab-402) antibody has been used in immunohistofluorescence.

生化／生理作用

Protein tyrosine kinase 2β(PTK2B) participates in the pathogenesis of Alzheimer′s disease (AD). It induces tumor progression in multiple myeloma. It helps in the multiplication, movement and survival of cells.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

標靶描述

Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.

外觀

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable