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重要文件

S7796

Sigma-Aldrich

紫苏雷素 硫酸盐

≥580 μg/mg (USP)

同義詞:

O-3-Deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->4)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1->6))-2-deoxy-L-streptamine sulfate (2:5) (salt)

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About This Item

經驗公式(希爾表示法):
C19H37N5O7 · 2.5H2O4S
CAS號碼:
分子量::
692.72
EC號碼:
分類程式碼代碼:
51281665
PubChem物質ID:
NACRES:
NA.85

形狀

powder

濃度

≥580 μg/mg (USP)

顏色

white to off-white

抗生素活性譜

Gram-negative bacteria

作用方式

protein synthesis | interferes

儲存溫度

−20°C

SMILES 字串

OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3OC(CN)=CC[C@H]3N)[C@@H]2O.CN[C@@H]4[C@@H](O)[C@H](OC[C@]4(C)O)O[C@H]5[C@H](N)C[C@H](N)[C@@H](O[C@H]6OC(CN)=CC[C@H]6N)[C@@H]5O

InChI

1S/2C19H37N5O7.5H2O4S/c2*1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;5*1-5(2,3)4/h2*3,9-18,24-27H,4-7,20-23H2,1-2H3;5*(H2,1,2,3,4)/t2*9-,10+,11-,12+,13-,14-,15+,16-,17-,18-,19+;;;;;/m11...../s1

InChI 密鑰

CIKNYWFPGZCHDL-ZHFUJENKSA-N

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一般說明

Chemical structure: aminoglycoside

應用

Sisomicin is an aminoglycoside antibiotic isolated from Micromonopora inyoensis. It is effective against most strains of Klebsiellk spp., Escherichia coli, P. aeruginosa, Enterobacter and Proteus spp.. It is a potential treatment for conjunctiva . It is used in disk and tube dilution sensitivity test.

生化/生理作用

Sisomicin interferes with protein synthesis at the level of functional ribosome assembly. The mechanism is similar to that of gentamycin. Sisomicin closely resembles gentamicin but is more effective against Pseudomonas aeruginosa and indole-positive Proteus.

包裝

250MG,1G,5G

儲存和穩定性

Keep container tightly closed in a dry and well-ventilated place.

其他說明

Keep container tightly closed in a dry and well-ventilated place.

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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分析證明 (COA)

Lot/Batch Number

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Gengrong Lin et al.
Antimicrobial agents and chemotherapy, 54(5), 2258-2261 (2010-02-11)
Synergy time-kill studies of 47 methicillin-resistant Staphylococcus aureus strains with differing resistance phenotypes showed that combinations of subinhibitory concentrations of ACHN-490 and daptomycin yielded synergy against 43/47 strains at 24 h, while the combination was indifferent against the remaining 4
Stephen Hanessian et al.
Chemical communications (Cambridge, England), 46(12), 2013-2015 (2010-03-12)
Aminoglycoside 66-40C, an unprecedented 16-membered bis-azadiene macrocyclic natural product isolated from the Micromonospora producer of the antibiotic sisomicin, was synthesized following a biomimetic strategy which definitively established its origin as arising from a remarkably selective non-enzymatic macro-dimerization.
Comparison of Preoperative 3-day Topical Levofloxacin versus 1-day Topical Sisomicin Sulfate in the Reduction of Bacterial Flora on Conjunctiva at the End of Cataract Surgery
Y. Kusano, T. Yamaguchi, et al.
Investigative Ophthalmology & Visual Science, 46, 4894-4894 (2005)
Clinical Pharmacology of Sisomicin
Victorio Rodriguez, Gerald P. Bodey, et al.
Antimicrobial Agents and Chemotherapy, 7, 182-195 (1975)
David Landman et al.
The Journal of antimicrobial chemotherapy, 65(10), 2123-2127 (2010-07-30)
Reports of Enterobacteriaceae resistant to all commonly used antimicrobial agents, including β-lactams, fluoroquinolones and aminoglycosides, are increasing in hospitals worldwide. The activity of ACHN-490, a next-generation aminoglycoside, was examined against clinical isolates of Escherichia coli and Klebsiella pneumoniae from hospitals

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