S6883

P 物质 乙酸盐 水合物

≥95% (HPLC), powder

• 經驗公式（希爾表示法）: C₆₃H₉₈N₁₈O₁₃S · xC₂H₄O₂ · yH₂O
• CAS號碼: 137348-11-9
• 分子量：: 1347.63 (anhydrous free base basis)
• Beilstein: 5153552
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24899725
• NACRES: NA.32

屬性

• 品質等級: 200
• 化驗: ≥95% (HPLC)
• 形狀: powder
• 分子量: 1348 Da by calculation (Average Mass)
• 儲存條件: (Keep container tightly closed in a dry and well-ventilated place.)
• 顏色: white
• 溶解度: 0.1 M acetic acid: 1 mg/mL
• UniProt登錄號: P20366
• 儲存溫度: −20°C
• SMILES 字串: [H]O[H].CC(O)=O.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O
• InChI: 1S/C63H98N18O13S.C2H4O2.H2O/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;1-2(3)4;/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);1H3,(H,3,4);1H2/t40-,41-,42-,43-,44-,45-,46?,47-,48-,49-;;/m0../s1
• InChI 密鑰: VHKFRLDSEZYWAC-CIYRQLMPSA-N
• 基因資訊: human ... TAC1(6863)

描述

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

一般說明

Research area: Cell Signaling

Substance P is a member of the tachykinin family of peptides. It is encoded by the tachykinin precursor 1 (TAC1) gene mapped to human chromosome 7q21-q22. Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.

應用

Substance P acetate salt hydrate has been:

• used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in mice
• administered in central nucleus (ACE) in rat to study its positive reinforcing effects
• used in competition binding assays
• used as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat

生化／生理作用

NK-1 激动剂；强效血管扩张剂和抗高血压剂；诱导唾液分泌；增加毛细血管通透性；诱导肥大细胞脱颗粒；感觉（疼痛）传入中的假定神经递质。

Substance P has proinflammatory effects on epithelial and immune cells. It has been associated with inflammatory diseases related to gastrointestinal and respiratory systems. Substance P modulates contractility of smooth muscles, transport of ions in the epithelium, vascular permeability and immune functions in the gut.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)