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Merck
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Key Documents

C2313

Sigma-Aldrich

化合物 48/80

powder,  hypotensive agent

同義詞:

Poly-p-methoxyphenethylmethylamine

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About This Item

分類程式碼代碼:
41106300
NACRES:
NA.77

product name

化合物 48/80,

形狀

powder

品質等級

溶解度

H2O: 50 mg/mL

儲存溫度

−20°C

一般說明

化合物48/80,是一种N-甲基p-甲氧基苯乙基胺和甲醛缩合产物。

應用

48/80化合物可用来:
  • 刺激血细胞释放组胺,从而通过ELISA和流式细胞仪测定
  • 诱发肥大细胞脱粒
  • 诱发小鼠过敏性活动、皮炎、瘙痒和炎症

生化/生理作用

化合物48/80是一种低血压药,促进组胺释放。C 48/80降低了 Styela plicata血细胞的吞噬能力。C 48/80 促进肥大细胞脱粒。它抑制钙调蛋白,磷脂酶C,内质网(ER)Ca2+磷酸酶和激活G蛋白。

準備報告

N-甲基-p-甲氧基苯乙基胺和甲醛缩合产物。

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


分析證明 (COA)

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Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKC alpha
Byrne RD, et al.
Cellular Signalling, 19(2), 321-329 (2007)
Meng-Li Wu et al.
Signal transduction and targeted therapy, 6(1), 428-428 (2021-12-19)
SARS-CoV-2 infection-induced hyper-inflammation links to the acute lung injury and COVID-19 severity. Identifying the primary mediators that initiate the uncontrolled hypercytokinemia is essential for treatments. Mast cells (MCs) are strategically located at the mucosa and beneficially or detrimentally regulate immune
Y Koibuchi et al.
European journal of pharmacology, 115(2-3), 163-170 (1985-09-24)
Compound 48/80 and 14C-labeled compound 48/80 were synthesized, and fractionated by thin-layer chromatography into 14 components (A-N) with various histamine releasing activities and different Ca2+ requirements for their actions. The histamine release induced from rat mast cells in vitro by
Radhika Palkar et al.
The Journal of investigative dermatology, 138(6), 1391-1399 (2017-12-31)
Cooling or the application of mentholated liniments to the skin has been used to treat itch for centuries, yet remarkably little is known about how counter-stimuli such as these induce itch relief. Indeed, there is no clear consensus in the
Development of a short-term canine full-thickness skin organ culture method under serum-free conditions
Abramo F, et al.
American Journal of Animal and Veterinary Sciences, 11(2), 61-69 (2016)

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