P8688

(S)-(-)-普奈洛尔 盐酸盐

≥98% (TLC), powder

• 同義詞: (S)-1-异丙基氨基-3-(1-萘氧基)-2-丙醇 盐酸盐
• 線性公式: C₁₀H₇OCH₂CH(OH)CH₂NHCH(CH₃)₂·HCl
• CAS號碼: 4199-10-4
• 分子量：: 295.80
• Beilstein: 3574966
• EC號碼: 224-096-0
• MDL號碼: MFCD00064547
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24278657
• NACRES: NA.77

屬性

• 品質等級: 200
• 化驗: ≥98% (TLC)
• 形狀: powder
• 光學活性: [α]25/D −25.5°, c = 1.0 in ethanol(lit.)
• mp: 193-195 °C (lit.)
• 溶解度: ethanol: 10 mg/mL; DMSO: <14.5 mg/mL; H₂O: 50 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
• 起源: AstraZeneca
• 儲存溫度: 2-8°C
• SMILES 字串: Cl[H].CC(C)NC[C@H](O)COc1cccc2ccccc12
• InChI: 1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H/t14-;/m0./s1
• InChI 密鑰: ZMRUPTIKESYGQW-UQKRIMTDSA-N
• 基因資訊: human ... ADRB1(153) , ADRB2(154) , ADRB3(155) , HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355)

描述

一般說明

With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.

應用

(S)-(−)-Propranolol hydrochloride has been used:

• as a non-selective β-blocker propranolol to inhibit the actions of epinephrine in mice
• as a β1- and β2-aadrenergic receptor blocker in rat
• as a medium supplement to investigate its effect on adipogenesis in hemangioma-derived stem cells (HemSC)

生化／生理作用

(S)-(−)-Propranolol hydrochloride is biologically active enantiomer. It acts as β1 receptor antagonist in thalamocortical neurons. (S)-(−)-Propranolol hydrochloride elicits its inhibitory function on the β1 adrenoceptor in trigeminovascular pain pathway and serves as a preventive medicine in migraine.

Active β-adrenoceptor blocking enantiomer, as measured by inhibition of isoprenaline-induced tachycardia; Propranolol is also non-specific 5-HT_1A, 5-HT_1B and 5-HT_1C serotonin receptor antagonist. The stereoselective association of mianserin and propranolol with the 5HT_1A, 5HT_1B and 5HT_1C sites may prove useful in the characterization of these sites

特點和優勢

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302 + H312 + H332
• 防範說明: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• 危險分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves