S2626

精脒

≥99% (GC)

• 同義詞: 1,8-二氨基-4-氮杂辛烷, N-(3-氨基丙基)-1,4-丁烷
• 線性公式: NH₂(CH₂)₃NH(CH₂)₄NH₂
• CAS號碼: 124-20-9
• 分子量：: 145.25
• Beilstein: 1698591
• EC號碼: 204-689-0
• MDL號碼: MFCD00008229
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24899529
• NACRES: NA.32

屬性

• 生物源: synthetic
• 品質等級: 200
• 化驗: ≥99% (GC)
• 形狀: solid or liquid (clear)
• 雜質: DNase, none detected; RNase, none detected; protease, none detected
• 折射率: n20/D 1.479 (lit.)
• mp: 22-25 °C
• 溶解度: water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
• 密度: 0.925 g/mL at 25 °C (lit.)
• 儲存溫度: room temp
• SMILES 字串: NCCCCNCCCN
• InChI: 1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
• InChI 密鑰: ATHGHQPFGPMSJY-UHFFFAOYSA-N
• 基因資訊: rat ... Ppm1a(24666)

描述

一般說明

一氧化氮合酶(nNOS)参与一氧化氮的生成。

Spermidine, a natural biomolecule, is known for its wide-ranging health benefits, including anti-inflammatory effects, antioxidant properties, and improvements in respiratory function. It carries a positive charge at physiological pH, allowing it to interact with oppositely charged DNA and RNA. Dietary intake of spermidine is associated with a reduced risk of neurodegeneration, metabolic diseases, heart ailments, and cancer. Spermidine-induced autophagy has been shown to slow the rate of cognitive decline by clearing amyloid-beta plaques in the brain. Spermidine supplementation improves mitochondrial metabolism and translational activity. Moreover, spermidine exhibits cell-autonomous effects on cancer cells and influences their communication with immune effectors, leading to the acceleration of tumor-associated antigen identification and cancer cell death. Spermidine-mediated autophagy inhibits the activation of apoptosis in cancer cells and is linked to tissue development and cell differentiation. This natural compound is additionally recognized for its neuroprotective, and anti-aging properties and is naturally found in semen, as well as in various plant sources.

應用

亚精胺已可用于：

• 制备5x转录缓冲液
• 与其他试剂一起处理双链RNA以增加线虫对dsRNA的摄取
• 作为大鼠脑多胺分析研究的标准(185)

生化／生理作用

抑制神经元型一氧化氮合成酶（nNOS）。结合和沉淀DNA，可用于DNA结合蛋白纯化。激活T₄聚核苷酸激酶活性。

注意

如果需要无菌溶液，则应采用无菌过滤而非高压灭菌。时间一长，亚精胺将发生脱氨基作用；溶液应采用冷冻保存。通常需要配制新溶液。

其他說明

惰性气体中保存。空气敏感；强吸湿性。

安全資訊

• 象形圖: GHS05
• 訊號詞: Danger
• 危險聲明: H314
• 防範說明: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• 危險分類: Eye Dam. 1 - Skin Corr. 1B
• 儲存類別代碼: 8A - Combustible, corrosive hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 233.6 °F - closed cup
• 閃點（°C）: 112 °C - closed cup
• 個人防護裝備: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter