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P7505

Sigma-Aldrich

腐胺 二盐酸盐

≥98% (TLC), powder

同義詞:

1,4-丁二胺 二盐酸盐, 1,4-二氨基丁烷 二盐酸盐, 四亚甲基二胺 二盐酸盐

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About This Item

線性公式:
NH2(CH2)4NH2 · 2HCl
CAS號碼:
分子量::
161.07
Beilstein:
3906680
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

product name

腐胺 二盐酸盐, ≥98% (TLC)

品質等級

化驗

≥98% (TLC)

形狀

powder

mp

280 °C (dec.) (lit.)

溶解度

H2O: soluble 100 mg/mL, clear, colorless

SMILES 字串

Cl[H].Cl[H].NCCCCN

InChI

1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H

InChI 密鑰

XXWCODXIQWIHQN-UHFFFAOYSA-N

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應用

腐胺二盐酸盐已用于:
  • 作为高效液相色谱(HPLC)的生物活性胺标准品
  • 作为杜氏改良Eagle培养基(DMEM)的激素混合物添加剂组分,研究其对神经干细胞的影响
  • 作为用于子宮內膜癌细胞培养的DMEM培养基的补充剂

生化/生理作用

结合到 NMDA 受体的聚胺调控位点并增强 NMDA 感应电流;亚精胺的前体。
腐胺是一种带正电荷的脂肪胺。可用作精胺前体,在聚胺生物合成中发挥作用。腐胺存在于几种植物、动物和细菌中。它在大肠杆菌细胞的增殖和生长中起作用。腐胺可用作农药、表面活性剂、药物、聚合物和添加剂中的组分。

象形圖

Skull and crossbonesCorrosion

訊號詞

Danger

危險分類

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 1

閃點(°F)

113.0 °F - closed cup

閃點(°C)

45 °C - closed cup

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Mito Kanatsu-Shinohara et al.
Methods in enzymology, 477, 17-36 (2010-08-12)
Spermatogonial stem cells (SSCs) in the testes are a new target for germline modification. With the development of an in vitro culture system and spermatogonial transplantation technique, SSCs can now be manipulated and used as an alternative to embryonic stem
Ulises Gómez-Pinedo et al.
Frontiers in neurology, 8, 255-255 (2017-06-22)
Alexander disease (AxD) is a rare disease caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). The disease is characterized by presence of GFAP aggregates in the cytoplasm of astrocytes and loss of myelin. Determine the effect
Jian Liu et al.
Journal of neuroscience research, 98(7), 1498-1513 (2020-03-14)
The neuroretina is protected by its own defense system, that is microglia and the complement system. Under normal physiological conditions, microglial activation is tightly regulated by the neurons although the underlying mechanism remains elusive. Using published single-cell RNA sequencing data
Yong Tao et al.
Human reproduction (Oxford, England), 30(8), 1867-1875 (2015-06-18)
Does peri-ovulatory putrescine supplementation of older mice improve oocyte quality and reduce the incidence of embryo resorption? Peri-ovulatory putrescine supplementation in older mice improved oocyte quality, as indicated by increased blastocyst cell numbers and reduced the incidence of embryo resorption.
Caterina Prelli Bozzo et al.
Nature communications, 12(1), 4584-4584 (2021-07-30)
Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- and anti-viral activities have been reported for coronaviruses. Here, we show that artificial overexpression of IFITMs blocks SARS-CoV-2 infection. However, endogenous IFITM expression supports efficient infection

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