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Merck
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重要文件

S0292

Sigma-Aldrich

水飞蓟素

flavonolignans

同義詞:

flavolignans

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About This Item

CAS號碼:
MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.81

生物源

plant (Silybum marianum)

形狀

powder

技術

toxicology assay: suitable

應用

microbiology

儲存溫度

−20°C

SMILES 字串

O1C(C(Oc3c1ccc(c3)C4Oc5c(c(cc(c5)O)O)C(=O)C4O)c2cc(c(cc2)O)OC)CO

InChI

1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3

InChI 密鑰

SEBFKMXJBCUCAI-UHFFFAOYSA-N

一般說明

水飞蓟素是一种黄酮木脂素,来自奶蓟(水飞蓟)植物。

應用

水飞蓟素已用于研究:
  • 体外抗病毒、抗菌、抗真菌活性及细胞毒性
  • 水飞蓟素对环磷酰胺 (CYP) 诱导的膀胱炎大鼠模型膀胱收缩的影响
  • 其对伏马菌素 B1 诱导的小鼠肝脏中毒的影响

生化/生理作用

水飞蓟素对大鼠缺血再灌注诱导的心肌梗死具有心脏保护活性。
水飞蓟素最初是众所周知的保护肝脏免受各种有毒物质侵害的药物,并用于治疗肝炎和肝硬化。水飞蓟素具有抗纤维化、抗脂质过氧化、抗炎、免疫调节和膜稳定等多种生物学作用。水飞蓟素还有助于肝再生。
水飞蓟素通过降低血清丙氨酸氨基转移酶 (ALT)、天门冬氨酸氨基转移酶 (AST) 和碱性磷酸酶 (ALP) 水平来保护肝脏免受抗结核药物的细胞毒作用。这种作用与水飞蓟素的抗氧化作用有关。

其他說明

水飞蓟 果实中抗肝毒性黄酮醇木脂素的混合物。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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文章

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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