RAB0161

磷酸化EGFR（pSer ¹⁰⁷⁰）ELISA试剂盒

for detection of human, mouse or rat phospho-egfr (pSer¹⁰⁷⁰) in cell and tissue lysates

• 分類程式碼代碼: 41116158
• NACRES: NA.32

屬性

• 物種活性: mouse, human, rat
• 技術: ELISA: suitable; capture ELISA: suitable
• 輸入: sample type tissue lysate; sample type cell lysate
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... EGFR(1965)

描述

一般說明

The Human BLC ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BLC in serum, plasma, cell culture supernatants and urine.
The EGFR (epidermal growth factor receptor) family includes four receptor tyrosine kinases, EGF R (ErbB1), ErbB2 (neu), ErbB3, and ErbB4. EGF R is present on many cell types of epithelial and mesenchymal lineages. The gene EGFR is mapped to human chromosome 7p11.2.

免疫原

EGFR (pTyr¹⁰⁷⁰) synthetic phosphopeptide

應用

请参考Protocol了解详情。

生化／生理作用

The members of epidermal growth factor receptor (EGF R) or the ErbB receptor family have been identified as useful biomarkers and targets for cancer therapy. EGF R binds EGF and induces tyrosine phosphorylation leading to proliferation of cells. EGF R is capable of binding transforming growth factor-α and heparin-binding EGF in addition to EGF. There are numerous effector molecules activated by EGF R that result in a variety of biological processes such as morphogenesis, cell motility, apoptosis, differentiation and organ repair and maintenance. Deregulation of EGF R signaling is implicated in progression of a wide variety of tumors, invasion and metastasis. Phosphorylation of Tyr1068 occurs by autophosphorylation of EGF R and is required for the binding of Grb2 (Growth factor receptor-bound protein 2) and activation of ERK1/2 (extracellular signal-regulated kinases) pathway.

安全資訊

• 象形圖: GHS05,GHS07
• 訊號詞: Warning
• 危險聲明: H290 - H335
• 危險分類: Met. Corr. 1 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 8A - Combustible, corrosive hazardous materials