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Merck
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Key Documents

R4393

Sigma-Aldrich

罗红霉素

95.0-102.0% (HPLC)

同義詞:

Erythromycin 9-(-O-[2-methoxyethoxy]methyloxime)

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About This Item

經驗公式(希爾表示法):
C41H76N2O15
CAS號碼:
分子量::
837.05
MDL號碼:
分類程式碼代碼:
51282308
PubChem物質ID:
NACRES:
NA.85

化驗

95.0-102.0% (HPLC)

形狀

powder or crystals

溶解度

chloroform: soluble 10 mg/mL

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

protein synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C(=N/OCOCCOC)\C(C)C(O)C1(C)O

InChI

1S/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/b42-31+

InChI 密鑰

RXZBMPWDPOLZGW-FEMONOMJSA-N

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一般說明

Chemical structure: macrolide

應用

Roxithromycin is a semi-synthetic macrolide antibiotic. Roxithromycin is used to block bacterial protein synthesis. Clinically, it is used to treat respiratory tract, urinary and soft tissue infections. It has a similar antimicrobial spectrum as erythromycin, but is the preferred treatment for certain gram-negative bacteria, such as Legionella pneumophila.

生化/生理作用

Roxithromycin impairs NADPH oxidase activation and alters translocation of its cytosolic components to the neutrophil membrane. It is similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, and clarithromycin. Roxithromycin binds to the subunit 50S of the bacterial ribosome, inhibiting the translocation of peptides.
Semisynthetic erythromycin derivative. Impairs NADPH oxidase activation and alters translocation of its cytosolic components to the neutrophil membrane.

包裝

1g,10g

其他說明

Keep container tightly closed in a dry and well-ventilated place.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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K Adrjanowicz et al.
Molecular pharmaceutics, 9(6), 1748-1763 (2012-05-01)
Antibiotics are chemical compounds of extremely important medical role. Their history can be traced back more than one hundred years. Despite the passing time and significant progress made in pharmacy and medicine, treatment of many bacterial infections without antibiotics would
X Wang et al.
Journal of veterinary pharmacology and therapeutics, 35(3), 282-289 (2011-07-14)
Tulathromycin is a macrolide antimicrobial agent proposed for therapeutic use in treatment of porcine and bovine respiratory disease. In this study, the absolute bioavailability of tulathromycin solution was investigated in pigs. Eight pigs, with body weight of 20.5 ± 1.6
Patorn Piromchai et al.
The Cochrane database of systematic reviews, (5)(5), CD008233-CD008233 (2011-05-13)
Chronic rhinosinusitis (CRS) is a common health problem which significantly affects quality of life. A wide range of medical and surgical therapies have been used to treat CRS. Both systemic and topical antibiotics are used with the aim of eliminating
Nikola Marjanović et al.
Pharmacological research, 63(5), 389-397 (2011-02-15)
Macrolide antibiotics are known to exert anti-inflammatory actions in vivo, including certain effects in COPD patients. In order to investigate the immunomodulatory profile of activity of macrolide antibiotics, we have studied the effects of azithromycin, clarithromycin, erythromycin and roxithromycin on
Z Samra et al.
Journal of chemotherapy (Florence, Italy), 23(2), 77-79 (2011-05-17)
The in vitro activity of tetracycline, doxycycline, erythromycin, roxithromycin, clarithromycin, azithromycin, levofloxacin and moxifloxacin was tested against 63 clinical isolates of Ureaplasma urealyticum. The minimal inhibitory concentrations (MICs) and the minimal bactericidal concentrations (MBCs) were determined by the broth microdilution

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