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Key Documents

Q2876

Sigma-Aldrich

喹吖因氮芥 二盐酸盐

≥85% (HPLC)

同義詞:

氮芥喹丫因 二盐酸盐, 氮芥喹丫因 二盐酸盐 二盐酸盐

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About This Item

經驗公式(希爾表示法):
C23H28Cl3N3O · 2HCl
CAS號碼:
分子量::
541.77
Beilstein:
3819822
EC號碼:
MDL號碼:
分類程式碼代碼:
12352101
PubChem物質ID:
NACRES:
NA.32

化驗

≥85% (HPLC)

儲存溫度

−20°C

SMILES 字串

Cl[H].Cl[H].COc1ccc2nc3cc(Cl)ccc3c(NC(C)CCCN(CCCl)CCCl)c2c1

InChI

1S/C23H28Cl3N3O.2ClH/c1-16(4-3-11-29(12-9-24)13-10-25)27-23-19-7-5-17(26)14-22(19)28-21-8-6-18(30-2)15-20(21)23;;/h5-8,14-16H,3-4,9-13H2,1-2H3,(H,27,28);2*1H

InChI 密鑰

JETDZFFCRPFPDH-UHFFFAOYSA-N

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一般說明

氮芥喹丫因(Quinacrine mustard dihydrochloride) 是一种荧光吖啶染料,简称QM。在水溶液中,氯乙基迅速失去氯离子,产生氮丙啶阳离子。这些阳离子很容易与蛋白质和核酸的羧基、硫醇和杂环氮基团或其他亲核试剂发生反应。

應用

氮芥喹丫因(Quinacrine mustard dihydrochloride)用于染色中期染色体。最新应用包括玉米的 Q 带分析和鱼类的核型分析。该染料还用作锥虫的活体染色剂。

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險分類

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


分析證明 (COA)

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D Fukushi et al.
Cytogenetics and cell genetics, 92(3-4), 254-263 (2001-07-04)
The DNA of Apodemus argenteus was digested with DraI, and the resultant DraI fragment of highly repetitive DNA was isolated and analyzed by DNA filter hybridization, cloning, sequencing, and fluorescence in situ hybridization (FISH). Southern blot hybridization and nucleotide sequencing
N Ye et al.
Mutation research, 435(1), 43-61 (1999-10-20)
An adaptive response, low doses of a mutagen rendering cells more able to subsequently cope with higher doses of that or a related challenging mutagen, enhances nucleotide excision repair in human fibroblasts. After fibroblasts were flashed with 20 J/m2 of
M Robinson et al.
British journal of haematology, 108(4), 859-864 (2000-05-03)
Animal in vivo biotinylation studies have demonstrated that thiazole orange (TO) labels the youngest cells in the circulation. TO has since been widely used for the measurement of reticulated platelets. As recent findings suggest that at high concentrations TO also
Diagnosis of triploidy in metaphases from uncultured amniocytes.
Vanna Pecile et al.
Prenatal diagnosis, 22(1), 78-79 (2002-01-26)
K Tanaka et al.
Biomedical chromatography : BMC, 3(6), 246-250 (1989-11-01)
A simple and precise method was developed for the separation of nucleosides including modified nucleosides and oligonucleotides. Nineteen kinds of nucleosides were completely separated by HPLC using an ODS column (TSK-gel ODS 80TM) and aqueous mobile phases. The RNA molecule

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