P7130

氨基核苷嘌呤霉素

• 同義詞: 3′-Amino-3′-deoxy-N⁶,N⁶-dimethyladenosine
• 經驗公式（希爾表示法）: C₁₂H₁₈N₆O₃
• CAS號碼: 58-60-6
• 分子量：: 294.31
• Beilstein: 93902
• EC號碼: 200-388-3
• MDL號碼: MFCD00063462
• 分類程式碼代碼: 51281912
• PubChem物質ID: 24898823
• NACRES: NA.85

屬性

• 形狀: powder
• 品質等級: 300
• 溶解度: H₂O: soluble 50 mg/mL
• 抗生素活性譜: Gram-positive bacteria; neoplastics; parasites
• 作用方式: protein synthesis | interferes
• 儲存溫度: 2-8°C
• SMILES 字串: CN(C)c1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H](N)[C@@H]3O
• InChI: 1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7+,9+,12-/m1/s1
• InChI 密鑰: RYSMHWILUNYBFW-VENHTOENSA-N

描述

一般說明

Puromycin aminonucleoside is the aminonucleoside portion of the antibiotic puromycin. It is useful in nephrology research, like studies of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats. The excretion of sodium and nitrite (NOx) metabolites in rats with puromycin aminonucleoside-induced nephrotic syndrome are studied. Puromycin aminonucleoside-induced nephrosis in rats has been studied with respect to the production of reactive oxygen species during the acute phase. Puromycin aminonucleoside is used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability.

應用

Puromycin aminonucleoside has been used:

• as a selection marker for the infected cells for the transfection of lentivirus
• as a component of fresh medium for transfection and infection assays
• to subcutaneously induce puromycin aminonucleoside nephrosis to investigate the mRNA and protein levels of nephrin and podocin before the onset of proteinuria

生化／生理作用

Puromycin aminonucleoside is used to study human glomerular disease by inducing damage of murine glomerular podocytes and is used to study glomerular function and morphology.

其他說明

Keep container tightly closed in a dry and well-ventilated place.

安全資訊

• 象形圖: GHS08
• 訊號詞: Warning
• 危險聲明: H373
• 危險分類: STOT RE 2
• 標靶器官: Kidney
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)