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Merck
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重要文件

P6500

Sigma-Aldrich

戊四唑

≥99% (GC), powder, CNS stimulant

同義詞:

1,5-五亚甲基-1H-四唑, 6,7,8,9-四氢-5H-四唑并氮杂卓, 戊四氮, 戊撑四唑

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About This Item

經驗公式(希爾表示法):
C6H10N4
CAS號碼:
分子量::
138.17
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

產品名稱

戊四唑,

形狀

powder

bp

194 °C/12 mmHg (lit.)

mp

59-61 °C (lit.)

儲存溫度

−20°C

SMILES 字串

C1CCc2nnnn2CC1

InChI

1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2

InChI 密鑰

CWRVKFFCRWGWCS-UHFFFAOYSA-N

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一般說明

戊四唑(PTZ)为四唑衍生物,是γ氨基丁酸(GABAA)及其受体复合物的抑制剂。 PTZ是用于诱发惊厥的惊厥剂。可穿透血脑屏障。

應用

戊四唑用于诱发斑马鱼幼虫 、小鼠 和雄性Wistar大鼠发生惊厥。

生化/生理作用

戊四唑是非特异性中枢神经系统(CNS)兴奋剂和惊厥剂。PTZ诱发氧化应激,增加皮质内丙二醛含量并影响海马体功能,导致发生惊厥。

象形圖

Skull and crossbones

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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分析證明 (COA)

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Effects of bee products on pentylenetetrazole-induced seizures in the rat
Zarraga-Galindo N, et al.
Proceedings of the Western Pharmacology Society, 54, 33-40 (2011)
Central nervous system uptake kinetics of pentylenetetrazol in the developing rat
Haberer LJ and Pollack GM
Biopharmaceutics & Drug Disposition, 12(1), 59-71 (1991)
Tatiana Afrikanova et al.
PloS one, 8(1), e54166-e54166 (2013-01-24)
Zebrafish have recently emerged as an attractive in vivo model for epilepsy. Seven-day-old zebrafish larvae exposed to the GABA(A) antagonist pentylenetetrazol (PTZ) exhibit increased locomotor activity, seizure-like behavior, and epileptiform electrographic activity. A previous study showed that 12 out of
Rufi Tambe et al.
Pharmaceutical biology, 55(1), 264-268 (2016-12-09)
Eclipta alba (Linn) Hassk. (Asteraceae) has been reported to be a nerve tonic and has been used to treat epilepsy in folk medicine. The present study isolates and characterizes luteolin from E. alba and evaluates its antiepileptic potential in chemically
Shehla Akbar et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 84, 962-971 (2016-10-21)
Diabetic neuropathy is the most prevalent, persistent and debilitating complication of diabetes mellitus often coupled with vulvodynia that may present as an isolated symptom or as a part of constellation of other neuropathic abnormalities. Flavonoids have selective affinity for GABA

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