P0357

Anti-p57^Kip2 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• 同義詞: Anti-Kip2
• MDL號碼: MFCD01633561
• 分類程式碼代碼: 12352203
• NACRES: NA.41
• 共軛: unconjugated
• application: IP; WB
• 無性繁殖: polyclonal
• 物種活性: human, mouse (predicted), bovine
• citations: 18
• 技術: immunoprecipitation (IP): 5 μg using 0.5-1 mg of HeLa nuclear extract and a bovine brain nuclear extract; western blot: 2 μg/mL using HeLa nuclear extract and bovine brain nuclear extract

屬性

• 生物源: rabbit
• 品質等級: 200
• 共軛: unconjugated
• 抗體表格: IgG fraction of antiserum
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen 57 kDa
• 物種活性: human, mouse (predicted), bovine
• 技術: immunoprecipitation (IP): 5 μg using 0.5-1 mg of HeLa nuclear extract and a bovine brain nuclear extract; western blot: 2 μg/mL using HeLa nuclear extract and bovine brain nuclear extract
• UniProt登錄號: P49918
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CDKN1C(1028) ; mouse ... Cdkn1c(12577)

描述

一般說明

Cyclin-dependent kinase inhibitor p57 (CDKN1C) or p57KIP2 (kinase inhibitory protein) is a tumor suppressor gene. It is a 316 amino acid protein with conserved amino- and carboxy-terminal domains and sequences with proline-alanine repeats. During mouse embryogenesis, p57KIP2 transcript is highly expressed in skeletal muscles, brain, heart, lungs and eye. The gene encoding this protein is localized on human chromosome 11p15.4.

免疫原

synthetic peptide corresponding to amino acids 303-316 of human Kip2, conjugated to KLH.

應用

Anti-p57Kip2 antibody produced in rabbit has been used in Western blotting.

生化／生理作用

Cyclin-dependent kinase inhibitor p57 (CDKN1C) or p57KIP2 (kinase inhibitory protein) plays a vital role as a tight-binding inhibitor of several G1 cyclin/cyclin-dependent kinase (CDK) complexes. It is a negative regulator of cell proliferation. Mutation in this gene has been associated with Beckwith-Wiedemann syndrome. p57Kip2 facilitates direct inhibition of DNA replication by binding to the proliferating cell nuclear antigen.

外觀

Solution in 0.1 M Tris-glycine, pH 7.4, containing 0.15 M NaCl, and 0.05% sodium azide.

準備報告

Purified using protein A

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable