SAB4500078

Anti-p15 INK antibody produced in rabbit

affinity isolated antibody

• 同義詞: CDKN2B, CDN2B, Cyclin-dependent kinase 4 inhibitor B, MTS2, Multiple tumor suppressor 2
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen 14 kDa
• 物種活性: mouse, human, rat
• 濃度: ~1 mg/mL
• 技術: ELISA: 1:5000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI登錄號: P42772
• UniProt登錄號: P42772
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CDKN2B(1030)

描述

一般說明

Anti-p15 INK Antibody detects endogenous levels of total p15 INK protein.

Cyclin-dependent kinase inhibitor 2B (CDKN2B) gene codes for tumor-suppressor p15INK4B protein. p15INK4B is a member of the INK4 family of protein kinase inhibitors. In bone marrow cells, p15INK4B expression is mainly seen at a high level in maturing monocytes/macrophages and lymphocytes. It is located in the nucleus and cytoplasm. The CDKN2B gene is mapped to human chromosome 9p21.3. Anti-p15 INK Antibody detects endogenous levels of total p15 INK protein.

免疫原

The antiserum was produced against synthesized peptide derived from human p15 INK.

Immunogen Range: 89-138

應用

Anti-p15 INK antibody produced in rabbit has been used in western blot (1:500).

生化／生理作用

Cyclin-dependent kinase inhibitor 2B (CDKN2B) plays a key role in the cell cycle and senescence. It participates in the differentiation of the hematopoietic cell. CDKN2B gene is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL). Homozygous deletion of the CDKN2B gene or p15INK4B locus on chromosome results in glioblastoma multiforme (GBM). Silencing of p15INK4B is associated with myelodysplastic syndromes, leukemia, and myeloproliferative diseases.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: nwg
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable