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About This Item
經驗公式（希爾表示法）:
C22H30O6
CAS號碼:
分子量：:
390.47
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
化驗
≥98% (HPLC)
形狀
powder
顏色
white
溶解度
DMSO: 10 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
C[C@@H]1C[C@]2(OC(C)=O)[C@H]([C@@H]3C=C(CO)C[C@@]4(O)[C@@H](C=C(C)C4=O)[C@@]13O)C2(C)C
InChI
1S/C22H30O6/c1-11-6-16-20(26,18(11)25)9-14(10-23)7-15-17-19(4,5)21(17,28-13(3)24)8-12(2)22(15,16)27/h6-7,12,15-17,23,26-27H,8-10H2,1-5H3/t12-,15+,16-,17-,20-,21+,22-/m1/s1
InChI 密鑰
BOJKFRKNLSCGHY-HXGSDTCMSA-N
應用
Prostratin已被用于逆转人类免疫缺陷病毒-1（HIV-1）的潜伏，并对潜伏HIV-1感染的Jurkat（J-Lat）细胞中长末端重复序列（LTR）的转录激活进行定量。
生化／生理作用
Prostratin是一种不常见的非致癌性佛波酯，它是蛋白激酶C（PKC）的激活剂，也是IKK（IKB激酶）激活介导的核因子KB（NF-KB）的激活剂。 Prostratin通过诱导潜伏感染细胞系和原代细胞的HIV表达而发挥有效的体外活性，从而对抗HIV潜伏。已有研究提出了其作用机制是激活PKC和NF-kB。Prostratin还通过下调CD4和CXCR4受体而抑制HIV进入靶细胞。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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Antiviral therapy, 9(4), 545-554 (2004-10-01)
Induction of HIV expression through lymphocyte activation has been proposed as a strategy to purge latent reservoirs. Prostratin is a non-tumourogenic phorbol ester that delays HIV replication in vitro, but paradoxically activates HIV expression in latently infected cells. To get
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文章
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