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Key Documents

O2750

Sigma-Aldrich

乳清酸

≥98% (titration), anhydrous

同義詞:

2,6-二羟基嘧啶-4-羧酸, 6-羧基-2,4-二羟基嘧啶, 尿嘧啶-6-羧酸, 脲嘧啶-6-羧酸

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About This Item

經驗公式(希爾表示法):
C5H4N2O4
CAS號碼:
分子量::
156.10
Beilstein:
383901
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

等級

anhydrous

化驗

≥98% (titration)

mp

≥300 °C

SMILES 字串

OC(=O)C1=CC(=O)NC(=O)N1

InChI

1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)

InChI 密鑰

PXQPEWDEAKTCGB-UHFFFAOYSA-N

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應用

乳清酸(OA)是从头嘧啶生物合成的中间体,可用于研究乳清酸磷酸核糖基转移酶(OPRT)的特异性和动力学,其催化从 5′-磷酸-α-d-核糖 1′-二磷酸(PRPP)到乳清酸(OA)的可逆磷酸核糖转移,形成焦磷酸盐和乳清酸 5′-单磷酸(OMP)。乳清酸用作通过产氨棒杆菌(ATCC 6872)或酿酒酵母等微生物潜在的商业生物生产尿苷 5′-单磷酸(UMP)的原料。乳清酸可用于研究 AMPK/SREBP-1 依赖性细胞信号传导途径,以及研究诱导肝脏脂肪生成的转录调节机制。

象形圖

Exclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Juliana Cheleski et al.
European journal of medicinal chemistry, 45(12), 5899-5909 (2010-10-23)
The enzyme dihydroorotate dehydrogenase (DHODH) has been suggested as a promising target for the design of trypanocidal agents. We report here the discovery of novel inhibitors of Trypanosoma cruzi DHODH identified by a combination of virtual screening and ITC methods.
David Pérez-Pascual et al.
Frontiers in microbiology, 8, 2168-2168 (2017-11-23)
A fascinating characteristic of most members of the genus
Thomas D Loan et al.
New biotechnology, 49, 104-111 (2018-10-23)
Nucleoside triphosphates (NTPs) are important synthetic targets with diverse applications in therapeutics and diagnostics. Enzymatic routes to NTPs from simple building blocks are attractive, however the cost and complexity of assembling the requisite mixtures of multiple enzymes hinders application. Here
Monika Feigenbutz et al.
PloS one, 8(11), e80752-e80752 (2013-11-14)
Rrp6 is a conserved catalytic subunit of the eukaryotic nuclear exosome ribonuclease complex that functions in the productive 3' end maturation of stable RNAs, the degradation of transiently expressed noncoding transcripts and in discard pathways that eradicate the cell of

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