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Key Documents

N9910

Sigma-Aldrich

β-烟酰胺腺嘌呤二核苷酸2′-磷酸,还原型 四钠盐

vial of 0.30-0.36 mg

同義詞:

β-NADPH, 2′-NADPH, NADPH Na 4, TPNH2 Na4, 磷酸二氢烟酰胺腺嘌呤二核苷酸 四钠盐, 还原型三磷酸吡啶核苷酸 四钠盐, 还原型辅酶 II 四钠盐

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About This Item

經驗公式(希爾表示法):
C21H26N7Na4O17P3
分子量::
833.35
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

形狀

solid

品質等級

包裝

vial of 0.30-0.36 mg

InChI

1S/C21H30N7O17P3.4Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;;;;/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35);;;;/q;4*+1/p-4/t10-,11+,13-,14+,15-,16+,20-,21+;;;;/m0..../s1

InChI 密鑰

WYWWVJHQDVCHKF-MPUNMZHWSA-J

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相關類別

應用

β-烟酰胺腺嘌呤二核苷酸 2′-磷酸盐 (NADP +) 和 β-烟酰胺腺嘌呤二核苷酸 2′-还原磷酸盐 (NADPH) 包含辅酶氧化还原对 (NADP +:NADPH),参与广泛的酶催化氧化还原反应。NADP + /NADPH 氧化还原对促进合成代谢反应中的电子转移,如脂质和胆固醇生物合成和脂肪酰基链的延长。NADP +/NADPH 氧化还原对被用于多种抗氧化机制,在该机制中可防止活性氧化物质积聚。NADPH 在体内通过磷酸戊糖途径 (PPP) 生成。

生化/生理作用

β-烟酰胺腺嘌呤二核苷酸 2′-磷酸(NADP+)和β-还原型烟酰胺腺嘌呤二核苷酸 2′-磷酸(NADPH)包含辅酶氧化还原对(NADP+:NADPH),参与多种酶催化的氧化还原反应。NADP+/NADPH 氧化还原对促进合成代谢反应中的电子转移,例如脂质和胆固醇的生物合成以及脂肪酰基链的延长。 NADP+/NADPH氧化还原对可用于多种抗氧化机制,从而保护抵抗反应性氧化物质的积累。NADPH 是通过戊糖磷酸途径(PPP)在体内产生的。

準備報告

化学还原

其他說明

根据 UV-Vis 测定的 NADPH 含量包装。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Zoltán Serfőző et al.
Cellular signalling, 30, 67-81 (2016-11-26)
Olfaction, a chemosensory modality, plays a pivotal role in the orientation and behavior of invertebrates. The central olfactory processing unit in terrestrial stylomatophoran snails is the procerebrum, which contains NO synthesizing interneurons, whose oscillatory currents are believed to be the
Laura Canevari et al.
Neurochemical research, 32(4-5), 739-750 (2006-12-28)
Since the discovery of the significance of the cholesterol-carrying apolipoprotein E and cholesterolaemia as major risk factors for Alzheimer's Disease (AD) there has been a mounting interest in the role of this lipid as a possible pathogenic agent. In this
Paul A Fraser
Free radical biology & medicine, 51(5), 967-977 (2011-06-30)
The brain endothelium constitutes a barrier to the passive movement of substances from the blood into the cerebral microenvironment, and disruption of this barrier after a stroke or trauma has potentially fatal consequences. Reactive oxygen species (ROS), which are formed
Estrogen signaling and neuroprotection in cerebral ischemia.
Brann D, Raz L, Wang R, et al.
Journal of Neuroendocrinology, 24(1), 34-47 (2011)
Grant R Drummond et al.
Nature reviews. Drug discovery, 10(6), 453-471 (2011-06-02)
NADPH oxidases are a family of enzymes that generate reactive oxygen species (ROS). The NOX1 (NADPH oxidase 1) and NOX2 oxidases are the major sources of ROS in the artery wall in conditions such as hypertension, hypercholesterolaemia, diabetes and ageing

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