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Merck
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Key Documents

N7778

Sigma-Aldrich

7-硝基吲唑

≥98%

同義詞:

7-NI

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About This Item

經驗公式(希爾表示法):
C7H5N3O2
CAS號碼:
分子量::
163.13
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98%

形狀

powder

溶解度

DMF: 50 mg/mL, clear, yellow to orange

儲存溫度

−20°C

SMILES 字串

[O-][N+](=O)c1cccc2cn[nH]c12

InChI

1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9)

InChI 密鑰

PQCAUHUKTBHUSA-UHFFFAOYSA-N

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生化/生理作用

小鼠大脑一氧化氮合酶的选择性抑制剂。

特點和優勢

该化合物在受体分类和信号转导手册的一氧化氮合酶页面上有重点介绍。想要浏览手册的其他页面, 请单击此处

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 1B

儲存類別代碼

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


分析證明 (COA)

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J Garthwaite
Trends in neurosciences, 14(2), 60-67 (1991-02-01)
Nitric oxide (NO) is a recently discovered and highly unorthodox messenger molecule. Current evidence indicates that, in the CNS, NO is produced enzymatically in postsynaptic structures in response to activation of excitatory amino acid receptors. It then diffuses out to
Philippe Bonnin et al.
International journal of molecular sciences, 21(18) (2020-09-12)
The poly(ADP-ribose) polymerase (PARP) inhibitor PJ34 has been reported to improve endothelial dysfunction in the peripheral system. We addressed the role of PJ34 on the vascular tone and vasoreactivity during development in the mouse brain. Blood flows were measured in
Morten Hedetoft et al.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc, 45(3), 335-350 (2018-07-22)
Experiments have shown that hyperbaric oxygen (HBO2) therapy reduces cyanide-induced cerebral distress. The exact mechanism behind HBO2's neuroprotective effect is unknown, but has been proposed to be mediated by an increased neuronal nitric oxide (NO) bioavailability, which may compete with
Anita J Turner et al.
American journal of physiology. Renal physiology, 313(4), F864-F873 (2017-07-07)
Via developmental programming, prenatal perturbations, such as exposure to glucocorticoids and maternal malnutrition alter kidney development and contribute to the development of hypertension. To examine the possibility that alterations in tubuloglomerular feedback (TGF) contribute to the development of hypertension in
Dongmei Wang et al.
Experimental neurology, 239, 111-119 (2012-10-16)
We have previously shown that intrathecal administration of the adrenomedullin (AM) receptor antagonist AM(22-52) produces a long-lasting anti-hyperalgesia effect. This study examined the hypothesis that AM recruits other pronociceptive mediators in complete Freund's adjuvant (CFA)-induced inflammation. Injection of CFA in

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