N3289

N2-Ethyl-2′-deoxyguanosine

≥98% (HPLC), solid

• 同義詞: N2-Et-dG
• 經驗公式（希爾表示法）: C₁₂H₁₇N₅O₄
• CAS號碼: 101803-03-6
• 分子量：: 295.29
• MDL號碼: MFCD01631004
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329818605
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: solid
• 顏色: white to off-white
• 溶解度: H₂O: >5 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: CCNC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](CO)O3)C(=O)N1
• InChI: 1S/C12H17N5O4/c1-2-13-12-15-10-9(11(20)16-12)14-5-17(10)8-3-6(19)7(4-18)21-8/h5-8,18-19H,2-4H2,1H3,(H2,13,15,16,20)/t6-,7+,8+/m0/s1
• InChI 密鑰: VOKQFDULHQUWAV-XLPZGREQSA-N

描述

一般說明

N2-Et-dG, an adduct between DNA and the first metabolite of ethanol (acetaldehyde), strongly blocks transcription by RNA polymerases (RNAPs), including mammalian RNAPII and yeast RNAPII, E. coli RNAP, as well as T7 RNAP. All three of the multisubunit RNAPs incorporate a single rNTP residue opposite the N2-Et-dG lesion. The mammalian RNAPII exclusively incorporates cytidine monophosphate (CMP) opposite the N2-Et-dG lesion. The accessory transcription factor TFIIS does not usually act as a lesion bypass factor; instead, it stimulates the polymerase to remove the CMP incorporated opposite the lesion by mammalian RNAPII. N2-Et-dG reduces CTP incorporation by ~1500 fold.

安全資訊

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H300 + H310 + H330,H351,H373
• 防範說明: P202 - P260 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• 危險分類: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Carc. 2 - STOT RE 2
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges