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一般說明
IgM抗体以五聚体的形式存在于血清中，其是通过对抗原的反应而产生的来源于鼠骨髓瘤的IgM, κ是由BAPC/c小鼠皮下注入的TEPC 183肿瘤细胞系产生的。
IgM是一种脊椎动物中高度保守的抗体，在免疫应答过程中早期表达。它是由腹膜B细胞分泌的。
Determined by the absorbance at 280 nm (E1%/280 = 11.8). Each vial contains at least 1 mg of purified myeloma protein.
特異性
TEPC 183肿瘤细胞系来源于原始诱导的浆细胞瘤，并在BALB/c小鼠皮下携带。TEPC 183细胞系的半抗原结合特异性尚未确定。它可特异性识别小鼠IgM。免疫球蛋白的识别性和纯度可通过免疫电泳进行确定。
應用
来自小鼠骨髓瘤的IgM, Kappa已被用于：
- 夹心法酶联免疫吸附试验 (ELISA)
- 流式细胞术
- 斑点免疫结合试验
生化／生理作用
IgM在凋亡细胞的吞噬中起关键作用。血清IgM水平降低会导致自身免疫反应增强，并增加感染风险。IgM显示出多反应和自动反应功能。它可通过介导基于组织的分子的清除在组织动态平衡中起关键作用。IgM具有与N-连接的糖基化位点，其中糖是甘露糖、半乳糖、N-乙酰氨基葡萄糖和唾液酸。IgM连接的琼脂糖树脂经检测是有效的结合物结合。
外觀
溶于含有0.05 M Tris(pH 8.0)、0.5 M氯化钠、0.02%叠氮化钠的溶液中
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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