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Merck
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Key Documents

M1574

Sigma-Aldrich

Miglitol

同義詞:

1-(2-Hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol

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About This Item

經驗公式(希爾表示法):
C8H17NO5
CAS號碼:
分子量::
207.22
EC號碼:
分類程式碼代碼:
12352205
NACRES:
NA.25

生物源

synthetic (organic)

品質等級

化驗

≥98% (HPLC)

形狀

powder

mp

142-147  °C

溶解度

water: 5 mg/mL, clear, colorless to faintly yellow

儲存溫度

room temp

InChI

1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1

InChI 密鑰

IBAQFPQHRJAVAV-ULAWRXDQSA-N

一般說明

Miglitol is an alpha-glucosidase inhibitor used as a glucose-lowering drug in diabetes research.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Kazutaka Aoki et al.
Acta diabetologica, 49(3), 225-230 (2011-09-08)
We recently reported that the administration of miglitol alone just before breakfast improved postprandial hyperglycemia and increased active glucagon-like peptide-1 (GLP-1) levels after lunch in men without diabetes. Miglitol and dipeptidyl peptidase-4 inhibitors, such as sitagliptin, enhance plasma active GLP-1
Takuo Emoto et al.
The American journal of cardiology, 109(1), 42-46 (2011-09-29)
Repeated postprandial hyperglycemia may play an important role in the development of atherosclerosis by suppressing vascular endothelial function. Although miglitol suppresses the elevation of blood glucose levels shortly after a meal more than other α-glucosidase inhibitors, the effect of 3-month
Kyra Jones et al.
Bioorganic & medicinal chemistry, 19(13), 3929-3934 (2011-06-15)
Inhibition of intestinal α-glucosidases and pancreatic α-amylases is an approach to controlling blood glucose and serum insulin levels in individuals with Type II diabetes. The two human intestinal glucosidases are maltase-glucoamylase and sucrase-isomaltase. Each incorporates two family 31 glycoside hydrolases
Kenichi Matsuura et al.
Diabetes technology & therapeutics, 14(5), 423-429 (2012-02-10)
We compared the effects of miglitol as an add-on to bolus insulin and dose-intensified bolus insulin on postprandial glycemic excursions by continuous glucose monitoring (CGM). The glucose levels of 21 type 2 diabetes patients admitted for glycemic control were monitored
Hongxiang Hui et al.
Chinese medicine, 4, 11-11 (2009-06-16)
Conventional drugs treat diabetes by improving insulin sensitivity, increasing insulin production and/or decreasing the amount of glucose in blood. Several herbal preparations are used to treat diabetes, but their reported hypoglycemic effects are complex or even paradoxical in some cases.

文章

Glucose metabolism is regulated by the opposing actions of insulin and glucagon. Insulin is released from pancreatic ß cells in response to high blood glucose levels and regulates glucose metabolism through its actions on muscle, liver, and adipose tissue.

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