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Key Documents

L9783

Sigma-Aldrich

亮肽素 盐酸盐

powder, ≥90% (HPLC)

同義詞:

Acetyl-Leu-Leu-Arg-al 盐酸盐

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About This Item

經驗公式(希爾表示法):
C20H38N6O4 · HCl
CAS號碼:
分子量::
463.01
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.77

product name

亮肽素 盐酸盐, microbial, ≥90% (HPLC)

生物源

microbial

品質等級

化驗

≥90% (HPLC)

形狀

powder

溶解度

water: 50 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

Cl.CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O

InChI

1S/C20H38N6O4.ClH/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);1H

InChI 密鑰

OQQYPQNFLLAILR-UHFFFAOYSA-N

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生化/生理作用

丝氨酸和半胱氨酸蛋白酶抑制剂。抑制纤溶酶、胰蛋白酶、木瓜蛋白酶、钙蛋白酶和组织蛋白酶 B。不抑制胃蛋白酶、组织蛋白酶 A 和 D、凝血酶或 α-糜蛋白酶。有效浓度 10-100 μM。已有许多研究使用亮肽素预防由声过度刺激或耳毒性抗生素庆大霉素引起的听力丧失。(耳蜗毛细胞的丢失被认为是由钙蛋白酶介导的。)

分析報告

亮肽素在溶液中形成互变异构体,因此HPLC分析时会出现多个峰。大多数污染性肽是外消旋化的亮肽素。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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